2024年12月24日 · CECR2 (CECR2 Histone Acetyl-Lysine Reader) is a Protein Coding gene. Diseases associated with CECR2 include Cat Eye Syndrome and Anus, Imperforate. Among its related pathways is Rett syndrome causing genes. An important paralog of this gene is BPTF.

2022年2月19日 · 他们确定了一个治疗靶点，一种称为猫眼综合征候选染色体区域2（cecr2）的基因，它增加了已扩散到远处器官的肿瘤中的表达。 研究小组发现，cecr2允许乳腺癌细胞迁移并侵入邻近组织，并逃避宿主免疫系统的监视。

cecr2 ，组蛋白乙酰赖氨酸阅读器： 预测该基因编码的蛋白可启动 atp 依赖性染色质重塑活性。 作用于内耳发育的上游或内耳发育；初级神经管形成；和单一施肥。

2022年2月5日 · 小鼠模型实验结果显示利用cecr2小分子抑制剂可以提高转移灶微环境的抗肿瘤免疫反应，进而抑制肿瘤细胞转移。 具体表现为减少惰性免疫微环境中的M2巨噬细胞和增加杀伤性CD8 T淋巴细胞数量。

2022年2月2日 · CECR2 was required for breast cancer metastasis in multiple mouse models, with more profound effect in the immunocompetent setting. Mechanistically, the nuclear factor κB (NF-κB) family member v-rel avian reticuloendotheliosis viral oncogene homolog A (RELA) recruits CECR2 to increase chromatin accessibility and activate the expression of ...

2025年1月4日 · Title: CECR2 drives breast cancer metastasis by promoting NF-κB signaling and macrophage-mediated immune suppression. A novel tumor suppressor CECR2 down regulation links glutamine metabolism contributes tumor growth in laryngeal squamous cell carcinoma.

The genes CECR2, SLC25A18 and ATP6V1E1, mapping within the critical region for cat eye syndrome (CES), may be responsible for anorectal, renal and preauricular anomalies in patients with CES. Cecr2 is important for gamma-H2AX formation and DNA double strand break repair, Cecr2 is a novel DNA damage response protein.

2022年2月2日 · CECR2 depletion suppresses NF-κB response genes, which results in a decrease of total macrophages, especially M2 macrophages in tumor microenvironment, and suppression of distal metastasis. Consistently, CECR2 inhibition suppresses breast cancer metastasis by decreasing M2 macrophages and enhancing antitumor immunity (fig. S12).

Herein we focused on CECR2, as it is an attractive targetable epigenetic regulator of breast cancer metastasis. Increased CECR2 mRNA concentrations in distant metastases were confirmed by RT-qPCR assays .

cecr2 组蛋白乙酰赖氨酸读取器： 该基因编码一种含溴结构域的蛋白质，该蛋白质参与染色质重塑，还可能在 dna 损伤反应中发挥作用。 编码的蛋白质作为参与神经形成的 ATP 依赖性复合物的一部分发挥作用。