Below are resources that may be helpful in gauging the spectrum of activity (how broad or narrow an antibiotic is) and figuring out what categories of bacteria might be treated by different antibiotic choices. This is a simplified table that shows the general pattern of activity of different antibiotics against major categories of bacteria.

2020年11月14日 · Continuing Education Activity. Cefepime, a potent cephalosporin belonging to the beta-lactam class of antibiotics, addresses a spectrum of bacterial infections caused by gram-negative and gram-positive organisms.

Cephalosporins are the largest group of beta-lactam antibiotics, cover a broad range of organisms, are generally well-tolerated, are easy to administer, and are thus frequently used. The classification, spectrum of activity, and pharmacology of the cephalosporins will be reviewed here.

2025年1月18日 · Spectrum of Activity. Cefepime’s broad-spectrum efficacy makes it a valuable asset in the therapeutic arsenal against diverse bacterial infections. Its activity spans a wide range of pathogens, effectively targeting both Gram-positive and Gram-negative bacteria.

2023年10月6日 · Including cases associated with concurrent bacteremia, P. aeruginosa, K. pneumoniae or Enterobacter species. Uncomplicated skin and skin-structure infections caused by MSSA or S. pyogenes.

2024年8月26日 · Expanded spectrum of activity compared with first and second generation cephalosporins and more active than third generation cephalosporins against Enterobacteriaceae that produce inducible β-lactamases.

Cefepime is active against Gram-positive and Gram-negative bacteria, and has greater activity against both compared to third-generation antibiotics. 1,4 Cefepime is normally used to treat severe nosocomial pneumonia and infections caused by multi-resistant microorganisms such as Pseudomonas aeruginosa, and is also indicated for the empirical ...

Cefepime is the most active 4th generation cephalosporin possessing the following advantages over the 3rd generation cephalosporins: high intrinsic potency due to rapid penetration into the periplasmic space; an extended spectrum of activity that includes many Gram-positive and Gram-negative organisms; Activity against multi-resistant Gram ...

Cefepime Antibiotic Class: Fourth-Generation Cephalosporin Antimicrobial Spectrum: Methicillin-susceptible Staphylococcus aureus (MSSA), Coagulase negative Staphylococci, Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, Neisseria meningitides, Neisseria gonorrhoeae, E. Coli, P. aeruginosa Mechanism of Action:

Cefepime possess higher in vitro activity than other extended-spectrum cephalosporins against common Gram-negative and Gram-positive pathogens. However, cefepime is ineffective against ESBL-producing Enterobacteriaceae, A. baumannii and highly derepressed AmpC-producing P. aeruginosa isolates.