2024年12月24日 · CELF1 (CUGBP Elav-Like Family Member 1) is a Protein Coding gene. Diseases associated with CELF1 include Myotonic Dystrophy and Myotonic Dystrophy 1. Among its related pathways are Processing of Capped Intron-Containing Pre-mRNA and Adipogenesis. Gene Ontology (GO) annotations related to this gene include nucleic acid …

2024年7月1日 · Among these proteins, the CUGBP Elav-like family (CELF) is a highly conserved group crucial for posttranscriptional regulation by binding to CUG repeats. Comprising CELF1–6, this family exhibits diverse expression patterns and functions.

CELF-5 provides clinicians with a streamlined, flexible battery to assess semantics, morphology, syntax, and pragmatics for students ages 5-21. CELF-5 features structured and authentic tests of language ability (including observational and interactive measures) for a complete picture of students' language skills.

2024年3月5日 · The CELF protein plays a crucial role in the gene regulatory network responsible for controlling how immune cells response to external stimuli. It also orchestrates the activation processes of immune cells. In quiescent T cells, CELF1 acts to inhibit the splicing of transcripts related to cellular proliferation.

CUG-BP, Elav-like family member 1 (CELF1) and CELF2 are RNA-binding proteins that regulate several stages of RNA processing, and are broadly expressed in developing and adult tissues. In this study, we investigated the expression patterns of CELF1 and CELF2 transcripts and proteins in different tissues, stages of development, and organisms.

2024年3月5日 · CUG-BP，Elav 样家族 1 (CELF1) 是 RBP CELF 家族的成员，与 mRNA 中富含 GU 的元件具有高亲和力，从而控制 mRNA 剪接、翻译和衰变等关键过程。 越来越多的研究表明CELF1与发生、发生和发展相关，是这些恶性疾病的潜在治疗靶点。 在此，我们介绍了CELF1的结构和功能，概述了其在多种稳态和疾病中的作用和调节机制，总结了已识别的CELF1调节因子及其构效关系，并展望了当前CELF1功能和疾病研究中面临的挑战和解决方案。 相应的药物发 …

As described below, CELF proteins from diverse species bind to RNA preferentially at GU-rich sequences and thereby regulate post-transcriptional processes such as mRNA splicing, translation, deadenylation and mRNA degradation. The structure and biochemical properties of CELF family members suggest functional redundancy [56], yet each CELF

CELF (CUG-BP and ETR-3-like factors) proteins are structurally related RNA-binding proteins involved in various aspects of RNA processing including splicing and mRNA stability. The first member of the family, CELF1/CUG-BP1, was identified through its role in …

CELF/BRUNOL 蛋白家族的成员包含两个 N 端 RNA 识别基序 (RRM) 结构域、一个 C 端 RRM 结构域，以及第二个和第三个 RRM 结构域之间的 160-230 aa 的不同片段。 该蛋白家族的成员调节 pre-mRNA 可变剪接，也可能参与 mRNA 编辑和翻译。 可变剪接导致编码不同异构体的多个转录变体。 [RefSeq 提供，2008 年 7 月]

2020年12月22日 · Using a massively parallel reporter assay framework, we test the consequence of CELF6 expression on target sequences, with and without mutating putative binding motifs. Where CELF6 exerts an effect on sequences, it is largely to decrease RNA abundance, which is reversed by mutating UGU-rich motifs.