2024年12月24日 · CELF2 (CUGBP Elav-Like Family Member 2) is a Protein Coding gene. Diseases associated with CELF2 include Developmental And Epileptic Encephalopathy 97 and Non-Specific Early-Onset Epileptic Encephalopathy. Among its related pathways is Processing of Capped Intron-Containing Pre-mRNA.

CELF/BRUNOL 蛋白家族的成员包含两个 N 端 RNA 识别基序 (RRM) 结构域、一个 C 端 RRM 结构域，以及第二个和第三个 RRM 结构域之间的 160-230 aa 的不同片段。 该蛋白家族的成员调节 pre-mRNA 可变剪接，也可能参与 mRNA 编辑和翻译。 可变剪接导致编码不同异构体的多个转录变体。 [RefSeq 提供，2008 年 7 月]

2025年2月9日 · RNA Binding Protein CELF2 Regulates Signal-Induced Alternative Polyadenylation by Competing with Enhancers of the Polyadenylation Machinery. CELF2 suppresses non-small cell lung carcinoma growth by inhibiting the PREX2-PTEN interaction.

2024年3月21日 · As a key member of RBPs, ELAV-like family protein 2 (CELF2) has been shown to regulate RNA splicing and embryonic hematopoietic development and was frequently seen dysregulated in acute myeloid...

2019年9月10日 · CELF2 is a member of the CUG-BP, Elav-like family (CELF) of binding proteins. It binds preferentially to single-stranded UG and CUG-rich RNA elements and has been widely studied as a regulator of splicing in heart and skeletal muscle, neurons, and T cells (Dasgupta and Ladd, 2012; Gazzara et al., 2017; Ladd et al., 2001).

本文将详细介绍CELF2基因的功能、作用机制、信号通路及其与疾病的关系，帮助读者全面了解这一重要的RNA结合蛋白基因。 CELF2基因：RNA世界的守护者 基因概述 CELF2，全称CUGBP Elav-like family member 2，位于人类染色体10p14位置。

2024年7月1日 · CELF2, previously known as mNapor, exhibits a temporal and spatial expression pattern that closely aligns with neuronal apoptosis, suggesting its involvement in central nervous system development by modulating apoptosis processes (Choi et al., 1999).

In this study, we demonstrate that the dynamic shuttling of an RBP, called CUGBP Elav-like family member 2 (CELF2, also known as CUG triplet-repeat RNA-binding protein 2/CUGBP2, ELAV-type RNA-binding protein 3/ETR-3, Bruno-like protein 3/ BRUNOL3 and neuroblastoma apoptosis-related RNA-binding protein/NAPOR), between the cytoplasm and nucleus is...

2021年6月8日 · In self-renewing NPCs, CELF2 resides in the cytoplasm, where it represses mRNAs encoding cell fate regulators and neurodevelopmental disorder-related factors. The translocation of CELF2 into the nucleus releases mRNA …

2019年8月13日 · Focusing on the context of breast cancer, we also demonstrate that CELF2 restoration has growth-inhibitory effects and that its epigenetic loss induces an aberrant downstream pattern of...