Characterization of a new surface epitope specific for human epithelial cells defined by a monoclonal antibody and application to tumor diagnosis. Two new human tumor cell lines derived from squamous cell carcinomas of the tongue: establishment, characterization and response to cytotoxic treatment. Eur. J. Cancer Clin. Oncol. 24:1445-1455 (1988)

2020年8月17日 · Our analysis of SINCs suggests that NPR1 is centrally integrated into the cell death or survival decisions in plant immunity by modulating multiple stress-responsive processes in this quasi-organelle. Eukaryotes have evolved mechanisms to effectively restrict infection while avoiding significant damage to self.

2020年8月20日 · Here we show that NPR1 promotes cell survival by targeting substrates for ubiquitination and degradation through formation of salicylic acid-induced NPR1 condensates (SINCs). SINCs are enriched with stress response proteins, including nucleotide-binding leucine-rich repeat immune receptors, oxidative and DNA damage response proteins, and ...

2011年8月7日 · Disrupting either RALA or RALBP1 leads to a loss of mitochondrial fission at mitosis, improper segregation of mitochondria during cytokinesis and a decrease in ATP levels and cell number. Thus, the two mitotic kinases Aurora A and cyclin B-CDK1 converge on RALA and RALBP1 to promote mitochondrial fission, the appropriate distribution of ...

2020年12月1日 · We tested the in vivo/in vitro anti-asthmatic effects of novel benzofuran, DK-1108. DK-1108 blocked inflammatory cytokines/chemokines and A549 to EOL-1 cell adhesion. DK-1108 reduced Th2 cytokine, IgE, cell influx, and ICAM-1/MCP-1 in asthmatic mice. DK-1108 protected asthmatic mice against airway inflammation/mucus hypersecretion.

Protein kinases that phosphorylate the alpha subunit of eukaryotic initiation factor 2 (eIF2alpha) are activated in stressed cells and negatively regulate protein synthesis. Phenotypic analysis of targeted mutations in murine cells reveals a novel role for …

Our data show that RiboLace is useful for ribosome purification and the co-purification of associated proteins, intact mRNAs, and nuclease-protected footprints using ∼40 times less material than classical ribosome profiling. RiboLace provides a valuable technique, with clear applications in vitro and in vivo.

2011年9月2日 · On page 1108 of this issue, Kashatus et al. add an interesting new dimension to our understanding of how mitochondrial fission is regulated during mitosis through DRP1 phosphorylation 9. DRP1 is...

Faculty Opinions recommendation of Acute stimulation generates Tim-3-expressing T helper type 1 CD4 T cells that persist in vivo and show enhanced effector function.

Phospho-eIF4G (Ser1108) Antibody detects eIF4GI only when phosphorylated at Ser1108. It does not cross-react with nonphosphorylated eIF4GI or p97. Human, Mouse, Rat, Hamster, Monkey, Bovine. Polyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Ser1108 of human eIF4GI.