VEGF in Signaling and Disease: Beyond Discovery and ... - Cell …
VEGF secreted by cancer and stromal cells stimulates the proliferation and survival of endothelial cells, leading to the formation of new blood vessels, often with impaired tight junctions and …
Disease-Causing Mutations in the G Protein Gαs Subvert ... - Cell …
2018年5月17日 · Here, we find that the R201C mutation can bypass the need for GTP binding by directly activating GDP-bound Gαs through stabilization of an intramolecular hydrogen bond …
Here, we demonstrated that adipose tissue-derived extracellular vesicles (EVs) and their cargo microRNAs (miRNAs) mediate inter-organ communication between adipose tissue and the …
miR-1264 Exacerbates Proliferation, Migration and Invasion of ...
2025年2月11日 · MiR-1264 acted as an oncogene in EC, promoting aggressiveness behaviors of EC cells by inhibiting MSH2. This study provided novel insights into anti-cancer treatment and …
SB 202190 | p38 MAPK | Tocris Bioscience
SB 202190 is a highly selective, potent and cell-permeable inhibitor of p38 MAP kinase. Binds within the ATP pocket of the active kinase (K d = 38 nM, as measured in recombinant human …
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全面解析！靶向VEGF重塑肿瘤微环境策略 - 知乎
本文将针对VEGF在TME中的作用以及靶向VEGF重塑TME的新策略进行简要阐述。 1. 肿瘤微环境TME 通常包括免疫细胞，基质细胞（包括癌症相关成纤维细胞、周细胞和间充质基质细胞）， …
HLA-DR15分子联合塑造多发性硬化症中的自身反应性T细胞库
2020年10月21日 · 瑞士苏黎世大学Roland Martin研究小组发现，HLA-DR15分子联合塑造多发性硬化症中的自身反应性T细胞库。 该研究于2020年10月21日在线发表于国际一流学术期刊《细 …
1264 - Gene ResultCNN1 calponin 1 [ (human)] - National Center …
results suggest that regulation of h1-calponin is involved in the regulation of differentiation of AR42J cells into insulin-producing cells; expression in tumor vessels is a new and useful …
CHOK1-CD16a-F158-Cell-Line - Kyinno Bio
Trusted Chinese hamster CHO-K1 cell line (KC-1264) for drug screening and biological assays. CHOK1 cell line stable expressing human FCGR3A amino acid bearing F158 mutation. Learn …
Frequent pathogenic mutations in G proteins can cause signaling activation by converting GDP into an activator, rather than locking the proteins at a GTP-bound state. The single most …
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