2022年4月1日 · Drug discovery efforts towards pore-blocking AQP inhibitors have made little progress. AQPs are dynamically relocalised between intracellular vesicles and plasma membrane. This relocalisation represents a new target for inhibition of AQP function.

2013年3月13日 · Aquaporins (AQPs) are water channel proteins that increase cell membrane water permeability and assemble in cell membranes as tetramers. AQP4, the main water channel in the CNS, is...

2020年5月14日 · Here we show that AQP4 cell-surface abundance increases in response to hypoxia-induced cell swelling in a calmodulin-dependent manner. Calmodulin directly binds the AQP4 carboxyl terminus, causing a specific conformational …

2013年1月21日 · Data from cell and animal models provide a compelling rationale for the development of aquaporin modulators as therapeutics: AQP1 inhibitors are predicted to have utility in diuretic-refractory edema, tumor angiogenesis and glaucoma; AQP4 inhibitors in some forms of brain edema and injury; and AQP3 inhibitors in some cancers.

2021年9月1日 · Regulation of osmotic homeostasis via AQPs is accompanied by dynamic participation of various cellular signaling pathways. Recently emerging evidence reveals that functional roles of AQPs are further extended from the osmotic regulation via water permeation into the cell proliferation and differentiation.

2017年10月8日 · 水通道蛋白（AQPs）是具有分泌和吸收功能的上皮细胞运输水的一类水膜通道，某些亚型也参与其他分子的运输，如甘油和尿素，在哺乳动物中有13种AQP成员 [6 - 7]。 近年来AQPs在肿瘤发展中的作用受到越来越多的关注。 已有的研究显示，AQPs在肿瘤细胞渗透压维持，调控肿瘤细胞迁移、细胞-基质粘附，促进肿瘤血管形成中扮演重要作用，AQPs还与癌基因、癌蛋白之间有着广泛的相互作用 [8 - 9]。 AQPs基于其特定的组织定位在几种类型肿瘤中表达有 …

Aquaporin (AQP) water channels are expressed primarily in cell plasma membranes. In this paper, we review recent evidence that AQPs facilitate cell migration. AQP-dependent cell migration has been found in a variety of cell types in vitro and in mice in vivo. AQP1 deletion reduces endothelial cell migration, limiting tumor angiogenesis and growth.

2012年3月30日 · In this study, we combined laser scanning confocal microscopy of chimeras of AQP1 with green fluorescent protein (AQP1-GFP), calcium imaging, and mutagenesis to determine that AQP1 translocation underpins the regulation of cellular water flow, as measured by changes in cell volume.

Some cell types, such as renal collecting duct cells, also permeate a larger quantity of water and in these cases the membrane water channel known as aquaporin (AQP) serves as the molecular machinery for such rapid and efficient transfer through the membrane, as first described by Agre and colleagues in 1992 .

2014年2月18日 · Here we show that membrane damage caused by ultra-quick freezing is rescued by the expression of AQP4. We next examine if the expression of AQP combined with ultra-quick freezing can be used to select cells efficiently under freezing conditions where most cells are died.