2016年11月8日 · We systematically characterised multifactorial multidrug resistance (MDR) in CEM/ADR5000 cells, a doxorubicin-resistant sub-line derived from drug-sensitive, parental CCRF-CEM cells developed...

2016年11月8日 · We systematically characterised multifactorial multidrug resistance (MDR) in CEM/ADR5000 cells, a doxorubicin-resistant sub-line derived from drug-sensitive, parental CCRF-CEM cells developed in vitro. RNA sequencing and network analyses (Ingenuity Pathway Analysis) were performed.

2013年7月16日 · We studied the antiproliferative effect of MnNG against drug resistant and sensitive T-lymphoblastic leukemia cells (CEM/ADR 5000 and CCRF/CEM). We also studied the anti-tumor activity of MnNG in vivo in drug resistant and sensitive Ehrlich ascites carcinoma (EAC/Dox and EAC/S) bearing Swiss albino mice. 2. Materials and methods. 2.1. Chemicals.

2021年11月1日 · In this study, we applied RNA sequencing, array comparative genomic hybridization (aCGH) and multicolor fluorescence in situ hybridization (mFISH) to analyze U87.MG glioblastoma cells and their transfected and drug-resistant subline, U87.MGΔEGFR, in order to identify genes, pathways, protein networks …

2012年9月15日 · After the successful synthesis of three artesunic acid homodimers connected by different types of chemical linkers, we analyzed their activity against human CCRF-CEM and multidrug-resistant P-glycoprotein-overexpressing CEM/ADR 5000 leukemia cells and observed, that multidrug resistant cells were not cross-resistant to the new compounds.

Moreover, S4 induces apoptosis in CEM/ADR 5000 cells through generation reactive oxygen species (ROS). This is substantiated by the fact that the antioxidant N-acetyle-cysteine (NAC) completely blocks ROS generation and, subsequently, abrogates S4 induced apoptosis.

2022年5月30日 · Novel 1,2,5-trisubstituted benzimidazole derivatives were designed, synthesized and evaluated for their cytotoxic effects in doxorubicin sensitive cell lines (CCRF/CEM and MCF7) and doxorubicin resistant cell lines (CEM/ADR 5000 and Caco-2).

Drug resistant CEM/ ADR 5000 cells following MnNG treatment for 24 h, 48 h and 72 h, showed a progressive increase in the percentages of sub-G 0 / G 1 cell population in a temporal manner (3.15%,...

We systematically characterised multifactorial multidrug resistance (MDR) in CEM/ADR5000 cells, a doxorubicin-resistant sub-line derived from drug-sensitive, parental CCRF-CEM cells developed...

2018年11月13日 · We investigated the influence of the three plant extracts and six major PSM from them (Figure 1) on the MDR cancer cells CEM-ADR 5000 and Caco-2 as compared to the sensitive CCRF-CEM and HCT-116 cells and explored their possible mechanisms.