CENPF is part of the nuclear matrix during the G2 phase of the cell cycle (the phase of rapid protein synthesis in preparation for mitosis). In late G2, the protein forms part of the kinetochore , a disc-shaped protein complex that allows the centromere of two sister chromatids to attach to microtubules (forming the spindle apparatus ) in order ...

2024年12月24日 · CENPF (Centromere Protein F) is a Protein Coding gene. Diseases associated with CENPF include Stromme Syndrome and Corpus Callosum, Agenesis Of . Among its related pathways are EML4 and NUDC in mitotic spindle formation and Separation of Sister Chromatids .

2025年3月5日 · Our findings suggest that cancer cells (CENPF+) play a central role in orchestrating the malignant evolution of LUAD and hold potential as a novel biomarker for early-stage detection and management...

2025年1月5日 · Title: Biallelic variants in CENPF causing a phenotype distinct from Strømme syndrome. Centromere protein F promotes progression of hepatocellular carcinoma through ERK and cell cycle-associated pathways.

该蛋白质是间期 G2 期核基质的组成部分。 在 G2 后期，该蛋白质与着丝粒结合，并在早期后期维持这种结合。 它分别定位于晚期后期和末期的纺锤体中区和细胞内桥，并且被认为随后被降解。 这种蛋白质的定位表明它可能在有丝分裂期间的染色体分离中发挥作用。 它被认为形成同二聚体或异二聚体。 在患有癌症或移植物抗宿主病的患者中发现了针对这种蛋白质的自身抗体。 [RefSeq 提供，2008 年 7 月] This gene encodes a protein that associates with the centromere …

2023年1月31日 · CENPF (centromere protein) is a key regulator of cell cycle progression, but its role in TNBC chemotherapy resistance remains unclear. Here, we found that CENPF, which is highly expressed...

CENPF (Centromere Protein F) is a nuclear—localized protein associated with the centromere and kinetochore complex (Li et al. 2020). It is involved in spindle assembly and chromosomal segregation during mitosis. When CENPF is misregulated, it can lead to genomic instability, a common characteristic in glioma cells (Hur et al. 2019).

HGNC Approved Gene Symbol: CENPF. The CENPF gene encodes a protein that is dynamically expressed throughout the cell cycle and is associated with the kinetochore and mitotic spindles (summary by Waters et al., 2015). Rattner et al. (1993) identified a human kinetochore protein with a molecular weight of approximately 400 kD.

Centromere protein F promotes progression of hepatocellular carcinoma through ERK and cell cycle-associated pathways. CENPF/CDK1 signaling pathway enhances the progression of adrenocortical carcinoma by regulating the G2/M-phase cell cycle.

Centromeric proteins (CENPs) family are involved in centromere formation and kinetochore organization during mitosis and play an important role in cancers. Here, we analyzed all CENPs in a panel of PC tissues and non-tumor tissues by genomics profile.