In most models of cerebellum function, the climbing fibers regulate movement by modulating the effectiveness of the mossy—parallel fiber connection with the Purkinje cells. The Purkinje cells project in turn to the deep cerebellar nuclei. They are the only output cells of the cerebellar cortex.

2021年5月10日 · For a proper understanding of cerebellar functional units, it is essential to know how mossy fiber (MF) and climbing fiber (CF) afferent systems interact within these cortical longitudinal zones, how PCs in these cortical longitudinal zones send output signals to the CN, and how these Purkinje cell output signals interact with nuclear ...

2020年1月1日 · Cerebellar neurons with distinct cytological and neurochemical properties reside in specific layers and sites of the cerebellum. They are connected with each other and also with specific brain regions outside the cerebellum (Fig. 4.1).

The cerebellar cortex is an important system for relating neural circuits and learning. Its promise has reflected the longstanding idea that it contains simple, repeated circuit modules with only a few cell types and a single plasticity mechanism ...

2024年1月8日 · The oft-lauded ‘highly stereotyped circuit architecture’ of the cerebellum refers mainly to the cerebellar cortex, in which molecularly identifiable neuronal cell types are not …

Recent investigations have shed light on the nature of cerebellar cognitive processing and information exchange with the neocortex. We review findings that demonstrate widespread reward-related cognitive input to the cerebellum, as well as new studies that have characterized the codependence of processing in the neocortex and cerebellum.

2013年1月9日 · The cerebellar circuit can be schematically described as follows: mossy fibers activate granule and Golgi cells in the granular layer. Granule cells emit parallel fibers and activate all the other neurons in the cerebellar cortex.

Within the cerebellar cortex, ongoing circuits driven by cerebellar input define cerebellar output. Based on comparisons of intended motion with actual perfomance, cerebellar output modifies activity in motor centers to correct detected errors of movement. Afferent axons to …

Metamorphosis of the cerebellar cortical circuit. The developing cerebellar circuit undergoes dramatic changes during postnatal development. Major components of the cerebellar circuit are illustrated at different developmental stages, corresponding to (a) postnatal week 1, (b) postnatal week 2, and (c) adult in rodent.

2024年10月20日 · This article highlights recent advances in our understanding of cerebellar cortex circuit structures, including greater heterogeneity among neuron types, previously unidentified synaptic connections, and more complex circuit organizations.