2024年12月24日 · CFH (Complement Factor H) is a Protein Coding gene. Diseases associated with CFH include Complement Factor H Deficiency and Hemolytic Uremic Syndrome, Atypical …

2023年12月20日 · The CFH gene is a gene that encodes the protein known as complement factor H (CFH). It is located on chromosome 1 and consists of multiple exons and introns. CFH plays …

2023年8月8日 · Complement factor H (CFH) negatively regulates consumption of complement component 3 (C3), thereby restricting complement activation. Genetic variants in CFH …

Factor H is a major soluble regulator of the alternative complement pathway, but it can also bind to host cells and tissues, protecting them from complement attack. Interactions of factor H with …

More than 100 mutations in the CFH gene have been identified in people with atypical hemolytic-uremic syndrome, a condition that causes abnormal blood clots (thrombi) to form in small …

2013年12月15日 · Genetic abnormalities within the CFHR gene locus can result in hybrid proteins with affected dimerization or recognition domains which cause defective functions. Here we …

2009年11月5日 · Extended haplotypes in the complement factor H (CFH) and CFH-related (CFHR) family of genes protect against age-related macular degeneration: characterization, …

Complement factor H (CFH), originally known as beta-1H globulin, is a serum glycoprotein that regulates the function of the alternative complement pathway in fluid phase and on cellular …

Variants in the complement factor H gene (CFH) are associated with age-related macular degeneration (AMD). CFH and five CFH -related genes (CFHR1-5) lie within the regulators of …

2023年7月10日 · Complement factor H (CFH), a major soluble inhibitor of complement, is a plasma protein that directly interacts with the endothelium of blood vessels. Mutations in the …