cGAS–STING cytosolic DNA sensing pathway is suppressed by …
2021年3月31日 · Cyclic GMP-AMP (cGAMP) synthase (cGAS), a cytosolic DNA sensor, catalyzes the synthesis of cyclic dinucleotide cGAMP, which binds and activates Stimulator of interferon …
p53 engages the cGAS/STING cytosolic DNA sensing pathway for …
2023年1月19日 · Since WTp53 activated the cGAS/STING pathway, we investigated if this resulted in differences in expression of interferon stimulated genes (ISGs) via Nanostring …
Nuclear cGAS suppresses DNA repair and promotes tumorigenesis
2018年10月24日 · We further observed a dose-dependent, stress-induced nuclear translocation of cGAS in two human lung cancer cell lines, A549 and PC-9 (Extended Data Fig. 2a–h). DNA …
IFN-γ activates the tumor cell-intrinsic STING pathway through the ...
cGAS is required for IFN-γ-induced STING activation. (a) Immunoblots showing cGAS expression in A549 and HCC827 cells treated with or without IFN-γ (100 IU/mL). (b) A549 and HCC827 …
Sci Adv：高清思路，浙大团队「细胞衰老+cGAS-STING」双热点 …
2024年8月21日 · 羟基脲 (HU) 是一种明确的 cGAS-STING 信号和细胞衰老的诱导剂，用羟基脲 (HU) 处理肠道上皮 DLD1 细胞，激活 STING 信号并导致 TBK1 和 IRF3 的磷酸化 (图 1A)。 …
Dengue virus activates cGAS through the release of ... - Nature
2017年6月15日 · The A549 cell line expresses functional cGAS that is capable of producing cGAMP in the presence of poly(dA:dT), ATP, and GTP when compared to THP-1 cells, a …
Lipopolysaccharide enhances DNA-induced IFN-β expression and ... - PubMed
Cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS) is a newly identified cytosolic DNA sensor, but its function in lung epithelial cells is relatively unknown. In …
Lipopolysaccharide enhances DNA-induced IFN-β expression …
In the present study, cGAS mediates A549 cellular responses against cytosolic DNA, providing evidence that cGAS are active in A549 cells. Although DNA is absent in the cytoplasm of lung …
上海市免疫学研究所邓刘福团队在Science Translational Medicine发文，揭示cGAS …
2020年6月27日 · 更加令人振奋的是，进一步应用人源化小鼠模型发现STING激动剂可以显著提高CAR-T细胞治疗A549实体瘤的效率。 该研究从免疫治疗面临的临床问题出发，深入研究 …
脂多糖通过上调A549细胞中cGAS的表达来增强DNA诱导的IFN-β表 …
在本研究中，研究了脂多糖（lps）对a549肺上皮细胞系中cgas表达和功能的影响。 用不同浓度（例如100、200、400和800 ng / ml）的LPS处理细胞，并通过蛋白质印迹分析和逆转录定量 …