【研究专题】免疫信号通路cGAS-STING - 知乎 - 知乎专栏
cgas-sting通路是细胞内重要的免疫信号通路，负责识别病毒和细菌的双链dna（dsdna）。 cGAS结合dsDNA后生成环状GMP-AMP（cGAMP），激活STING（刺激性基因）。 活化 …
The CRL5–SPSB3 ubiquitin ligase targets nuclear cGAS for ... - Nature
2024年2月28日 · Cyclic GMP-AMP synthase (cGAS) senses aberrant DNA during infection, cancer and inflammatory disease, and initiates potent innate immune responses through the...
Cancer-Cell-Intrinsic cGAS Expression Mediates Tumor Immunogenicity
2019年10月29日 · We find that cancer cells produce cGAMP that is transferred via gap junctions to tumor-associated dendritic cells (DCs) and macrophages, which respond by producing type …
Engineering cGAS-agonistic oligonucleotides as therapeutics for …
2024年3月12日 · The cGAS-STING immunostimulation pathway plays a critical role in innate immunity that mediates anti-cancer therapies, including ICB. Upon dsDNA binding, cGAS is …
文献分享 | Nature Reviews Immunology：cGAS-STING通路作为炎 …
2024年12月27日 · 对cGAS-STING通路的结构和分子生物学的深入理解，使得开发选择性小分子抑制剂成为可能，这些抑制剂可以在多种人类炎症性疾病中靶向cGAS-STING轴。 在本文中， …
cGAS-activated endothelial cell–T cell cross-talk initiates tertiary ...
2024年8月2日 · Hyperactivation of cGAS resulted in the formation of tertiary lymphoid structures (TLSs) in the lung, which enhanced antibody responses and antitumor immunity. CCL5 …
Manganese is critical for antitumor immune responses via cGAS …
2020年8月24日 · Antitumor immunity depends on the activation of the cGAS-STING pathway, as STING-deficient mice fail to stimulate tumor-infiltrating dendritic cells (DCs) to activate CD8 + …
ER-directed TREX1 limits cGAS activation at micronuclei
Here, we use micronuclei purification to show that the endoplasmic reticulum (ER)-associated nuclease TREX1 inhibits cGAS activation at micronuclei by degrading micronuclear DNA upon …
The multiple faces of cGAS-STING in antitumor immunity
2024年4月15日 · As a key sensor of double-stranded DNA (dsDNA), cyclic GMP-AMP synthase (cGAS) detects cytosolic dsDNA and initiates the synthesis of 2'3' cyclic GMP-AMP (cGAMP) …
FACS（流式细胞荧光分选技术）_百度百科
流式细胞仪 的工作原理是将待测细胞经特异性 荧光染料 染色后放入样品管中，在气体的压力下进入充满鞘液的流动室。 在鞘液的约束下细胞排成单列由流动室的喷嘴喷出，形成细胞柱，后 …