2018年10月4日 · The capsid protein, which associates with viral DNA, has a pivotal role in enabling cGAS-mediated immune activation. We now find that NONO is an essential sensor of the HIV capsid in the nucleus. NONO protein directly binds capsid with higher affinity for weakly pathogenic HIV-2 than highly pathogenic HIV-1.

2022年10月26日 · We found that genetic reversal of two specific amino acid adaptations in HIV-1 (M) enables activation of TRIM5, cGAS and innate immune responses. We propose a model in which the parental...

2018年10月4日 · We now find that NONO is an essential sensor of the HIV capsid in the nucleus. NONO protein directly binds capsid with higher affinity for weakly pathogenic HIV-2 than highly pathogenic HIV-1. Upon infection, NONO is essential for cGAS activation by HIV and cGAS association with HIV DNA in the nucleus.

2013年8月8日 · Here we show that HIV infection activates cyclic guanosine monophosphate–adenosine monophosphate (cGAMP) synthase (cGAS) to produce cGAMP, which binds to and activates the adaptor protein STING to …

揭示了cGAS-STING 通路在识别胞质DNA、诱导产生Ⅰ型干扰素、激发人体天然免疫反应过程中的重要作用。引人关注的是HIV 等逆转录病毒能激动cGAS-STING 通路。此研究成果相继发表在Science、Cell 等各大期刊杂志。

5 天之前 · Here, we show that HIV-1 uses chromatin-mediated cGAS inactivation as a mechanism to protect its uvDNA from innate immune activation. Keywords: HIV; cGAS; chromatin; innate immunity. To ensure optimal replication and spread, viruses have evolved countermeasures to evade type 1 IFN-mediated antiviral activity.

2016年10月12日 · In this study, we found that active cGAS and HIV-1 Env expression in donor cells enable transfer of cGAMP to macrophages through HIV-1 Env and receptor/coreceptor-mediated membrane fusion sites, followed by cGAMP binding to STING, thus triggering a TBK-1-dependent type I IFN response in a fashion that bypasses the necessity of functional cGAS ...

The cyclic GMP-AMP synthase (cGAS)–stimulator of interferon genes (STING) DNA pathway has emerged as a key innate immune pathway important for antiviral immunity. cGAS binds to double-stranded DNA and catalyzes the production of the second messenger 2′3′-cyclic GMP-AMP, a diffusible cyclic dinucleotide that activates the endoplasmic ...

2025年1月28日 · Retroviruses can be detected by the innate immune sensor cyclic GMP-AMP synthase (cGAS), which recognizes reverse-transcribed DNA and activates an antiviral response. However, the extent to which HIV-1 shields its genome from cGAS recognition remains unclear.

2015年6月4日 · Polyglutamine binding protein 1 (PQBP1) is a sensor of HIV-1 infection, directly binding to reverse-transcribed HIV-1 DNA and interacting with cGAS to initiate an IRF3-dependent innate response in dendritic cells.