The CRL5–SPSB3 ubiquitin ligase targets nuclear cGAS for ... - Nature
2024年2月28日 · Here we show that the ubiquitin proteasomal system (UPS) degrades nuclear cGAS in cycling cells. We identify SPSB3 as the cGAS-targeting substrate receptor that …
3篇Nature+2篇Science | 细胞核内cGAS和核小体结合并抑制其催化 …
2020年9月9日，美国德克萨斯A & M大学化学系 刘文设 教授和生物化学与生物物理系 李平卫 教授团队在 Nature 期刊上发表文章：The molecular basis of tight nuclear tethering and …
The Cytoplasmic DNA Sensor cGAS Promotes Mitotic Cell Death …
Pathogenic and other cytoplasmic DNAs activate the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway to induce inflammation via transcriptional …
The cGAS/STING/TBK1/IRF3 innate immunity pathway maintains
2020年4月13日 · Here, we demonstrate for the first time that stably decreasing cGAS expression levels in different cancer cell lines (HeLa and U2OS) facing nocodazole-induced mitotic arrest …
DNA-induced liquid phase condensation of cGAS activates ... - Science
2018年7月5日 · Cyclic GMP–AMP synthase (cGAS) is a DNA-sensing enzyme that catalyzes the conversion of GTP and ATP to cyclic GMP–AMP (cGAMP), which activates the adaptor …
A Nuclear Export Signal Is Required for cGAS to Sense Cytosolic …
2021年1月5日 · Time-lapse cell imaging was used to investigate the cellular localization of cGAS in HeLa cells treated with ISD, and a robust cytoplasmic accumulation of cGAS was seen …
PRMT1 mediated methylation of cGAS suppresses anti-tumor …
2023年5月17日 · Here, we report that the protein arginine methyltransferase, PRMT1, methylates cGAS at the conserved Arg133 residue, which prevents cGAS dimerization and suppresses …
看19年Cell是怎么把cGAS促进细胞死亡讲明白的 - 知乎
细胞质DNA感受器cGAS（cyclic GMP-AMP synthase，环鸟苷酸-腺苷酸合成酶）的激活在正常有丝分裂过程中会被核小体抑制，但是在有丝分裂阻滞时，cGAS会通过缓慢的积累IRF3的磷酸 …
Unintegrated HIV-1 DNA recruits cGAS via its histone-binding
The observation that disruption of the uHIV1 chromatin structure results in cGAS activation prompted us to explore whether uHIV-1 DNA may recruit cGAS via its binding to H2A/H2B …
Phosphoinositide Interactions Position cGAS at the Plasma …
2019年3月7日 · The enzyme cGAS is a sensor of cytosolic DNA that induces interferon and inflammatory responses that can be protective or pathologic, depending on the context. Along …