DNA-induced liquid phase condensation of cGAS activates innate …
2018年8月17日 · The binding of DNA to cyclic GMP-AMP synthase (cGAS) leads to the production of the secondary messenger cyclic GMP-AMP (cGAMP), which activates innate …
AARS1 and AARS2 sense l -lactate to regulate cGAS as global
2024年9月25日 · By establishing a genetic code expansion orthogonal system for lactyl-lysine incorporation, we demonstrate that the presence of a lactyl moiety at a specific cGAS amino …
Liquid–liquid phase separation drives cellular function and
2022年2月11日 · Biomolecular condensates are widely observed to directly regulate key cellular processes involved in cancer cell pathology, and the dysregulation of LLPS is increasingly …
DNA-induced liquid phase condensation of cGAS activates ... - Science
2018年7月5日 · Du and Chen show that DNA binding to its cytoplasmic sensor, cyclic GMP–AMP synthase (cGAS), results in liquid droplets containing activated cGAS (see the Perspective by …
Mechanisms of phase-separation-mediated cGAS activation …
2022年7月8日 · DNA-induced LLPS of cGAS, driven by multivalent interactions between cGAS and DNA, is essential in vivo to induce cGAS activation and to trigger the cGAS–STING …
Liquid-liquid phase separation: Orchestrating cell ... - Cell Press
2021年10月21日 · cGAS LLPS depends not only on the concentration of dsDNA but also its length, with longer dsDNA providing more binding sites and thus greater multivalency. In …
PNAS丨高大兴、项晟祺揭示cGAS蛋白的相变和酶活的调控机制|活性|dna|pnas|cgas…
2025年1月26日 · cGAS （环磷酸鸟苷-腺苷合酶） 是一种关键的胞质DNA传感器，能够识别细胞质中的双链DNA （dsDNA） ，并催化ATP和GTP合成环状小分子cGAMP 【1, 2】。 cGAMP作 …
Stress granule-localized USP8 potentiates cGAS-mediated type I ...
2024年6月25日 · Cyclic GMP-AMP synthase (cGAS) undergoes liquid-liquid phase separation (LLPS) to trigger downstream signaling upon double-stranded DNA (dsDNA) stimulation, and …
液-液相分离调节免疫细胞活化和关键信号传导的研究进展 - PMC
进而得出结论，保护 dna免受trex1降解可能是cgas llps促进dna感知的主要模式。研究人员通过免疫亲和纯化技术和免疫荧光染色实验发现，除dna外，多种rna结合蛋白虽然不能诱导cgas产 …
Mechanisms of phase-separation-mediated cGAS activation
2022年7月8日 · Cyclic GMP-AMP synthase (cGAS), as a DNA sensor, plays an important role in cGAS-STING pathway, which further induces expression of type I interferon as the innate …