Monoclonal Antibody for studying cGAS. Validated for WB, WB. Available in 2 sizes. Highly specific and rigorously validated in-house, cGAS (D1D3G) Rabbit Monoclonal Antibody (CST #15102) is ready to ship.

29958-1-AP targets cGAS in WB, IHC, IF/ICC, ELISA applications and shows reactivity with human, mouse samples.

Antibodies that detect cGAS can be used in several scientific applications, including Western Blot, ELISA, Immunoprecipitation, Immunohistochemistry and Immunocytochemistry. These antibodies target cGAS in Human, Mouse, Rat and Porcine samples. Our cGAS polyclonal, monoclonal and recombinant monoclonal antibodies are developed in Rabbit and Mouse.

cGAS -STING 信号通路是先天免疫的重要通路之一，其由环磷酸鸟苷-磷酸腺苷酸合成酶(cyclic GMP-AMP synthase, cGAS)、干扰素基因刺激物(stimulator of interferon gene, STING)和一系列下游信号转导接 头分子及效应分子共同组成。

cGAS抗体（C-1）是一种小鼠单克隆IgM抗体，可通过蛋白质印迹（WB）、免疫沉淀（IP）、免疫荧光（IF）、石蜡包埋切片免疫组织化学（IHCP）和酶联免疫吸附测定（ELISA）检测人类来源的cGAS蛋白。 抗cGAS抗体（C-1）以非结合形式提供。 cGAS蛋白（又称MB21D1）作为胞浆DNA传感器在先天免疫反应中发挥着关键作用。 当在细胞质中检测到外来DNA时，cGAS会催化ATP和GTP合成环状GMP-AMP（cGAMP），随后激活干扰素基因刺激因子（STING）通 …

重组蛋白ng级别WB保证的单克隆抗体; 30天快速单抗定制开发 - PETAL; 蛋白修饰位点特异单克隆抗体

cGAS Antibody (D-9) is a mouse monoclonal IgG2a kappa light chain antibody that detects cGAS of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). anti-cGAS antibody (D-9) is available in both non-conjugated and various conjugated forms ...

cGAS-STING通路是细胞内重要的免疫信号通路，负责识别病毒和细菌的 双链DNA （dsDNA）。 cGAS结合dsDNA后生成环状GMP-AMP（cGAMP），激活STING（刺激性基因）。 活化的STING进一步招募 TBK1 并激活 IRF3，促进 I型干扰素 和炎症因子的表达，从而增强免疫反应。 该通路在抗病毒、抗肿瘤和自身免疫疾病中具有重要作用，是医学研究的潜在靶点。 cGAMP的合成是启动cGAS介导抗病毒效应的关键步骤。 在哺乳动物中，cGAS的活性通过与双 …

2022年4月21日 · 通过wb和qpcr实验，在蛋白和基因水平上，证明了外源il-1β对irf3的激活依赖于cgas和sting通路。 并且，通过免疫荧光，表明了il-1β的诱导也会促进sting在核周的重定位。 3. 实验三

84045-1-RR targets cGAS in WB, IF/ICC, ELISA applications and shows reactivity with mouse samples. PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Dual-tDCS Ameliorates Cerebral Injury and Promotes Motor Function Recovery via cGAS-STING Signaling Pathway in a Rat Model of Ischemic Stroke

2024年5月13日 · cgas-sting dna感应信号通路： 脊椎动物中细胞内dna的主要传感器是环化gmp-amp合成酶（cgas）。cgas以序列无关的方式结合双链dna（dsdna）的糖磷酸骨架，导致结构重排激活gtp和atp生成环化gmp-amp（cgamp）。

2024年12月24日 · CGAS (Cyclic GMP-AMP Synthase) is a Protein Coding gene. Diseases associated with CGAS include Covid-19 and Severe Covid-19. Among its related pathways are Cytosolic sensors of pathogen-associated DNA and Innate Immune System. An important paralog of this gene is ITPRIPL2.

2025年2月26日 · Cyclic GMP-AMP synthase (cGAS), a critical cytosolic DNA sensor initiating innate immune responses in the presence of cytosolic DNA, is increasingly recognized as a promising therapeutic target for ulcerative colitis (UC). Here, we reported the design, synthesis, structure–activity relationship exploration and biological evaluation of a novel class of CRBN-recruiting cGAS-targeting PROTAC ...

1 天前 · cGAS inhibition suppresses tumor growth and sensitizes DLBCL cell lines to ferroptosis. March 14, 2025. Researchers from Soochow University and affiliated organizations presented data from a study that aimed to investigate the role of cyclic GMP-AMP synthase (cGAS) in tumorigenesis and tumor progression. ... Design, CMS, Hosting & Web ...