2002年11月4日 · In the present study, we examined the CGE at E13.5. Although the CGE shares the expression of certain markers with the LGE or the MGE, gene expression in the CGE matches neither region...

We set two criteria with the Affymetrix Microarray Suite software to identify candidates for genes that are specifically expressed in the CGE: (1) expressed in the CGE (“Present call” for the CGE) but not in the LGE and MGE (“Absent call” for the LGE and MGE), (2) significantly higher expression in the CGE than in the LGE and MGE ...

2005年11月23日 · At E13.5, the MGE gives rise to fast-spiking (FS) interneurons, whereas the CGE generates predominantly regular-spiking interneurons (RSNP). Later at E15.5, the CGE produces RSNP classes distinct from those generated from the E13.5 CGE.

2016年5月15日 · Here, we unravel the existence of two novel CGE caudo-rostral migratory streams, one located laterally (LMS) and the other one more medially (MMS), that, together with the well-known caudal migratory stream (CMS), contribute to populate the neocortex, hippocampus and amygdala.

2021年9月22日 · To explore whether there is an earlier chromatin signature that is indicative of interneuron identity, we compared the RNA expression and chromatin accessibility in these precursor populations at...

load 10x data and subset to E13.5 Lhx6neg (CGE) re-normalize data and run maturation trajectory analysis to isolate post-mitotic cells; cluster cells and remove Lhx6 positive clusters (contamination) also load the 10x E13.5 Lhx6pos (MGE) cells; map both set of cells to the branches identified in E13.5 dropseq data

2019年5月15日 · NCBI's Gene Expression Omnibus (GEO) is a public archive and resource for gene expression data.

2014年12月3日 · We show that NPAS1 and NPAS3 transcription factors (TFs) are expressed in progenitor domains of the mouse basal ganglia (subpallium, MGE, and CGE). NPAS1−/− mutants had increased proliferation, ERK signaling, and expression of Arx in the MGE and CGE.

2019年1月1日 · This transplantation study has demonstrated that the E13.5 MGE contributes to the Pvalb (Parvalbumin) and Sst interneurons and the CGE at E13.5 and E15.5 gives rise to distinct types of Vip (Vasoactive intestinal polypeptide)-positive populations.

2005年11月23日 · Later at E15.5, the CGE produces RSNP classes distinct from those generated from the E13.5 CGE. Thus, we provide evidence that the spatial and temporal origin of interneuron precursors in the developing telencephalic eminences predicts the intrinsic physiological properties of mature interneurons.