Murine chronic graft-versus-host disease as a model of systemic …
The effect of a number of drugs commonly used to treat the more severe exacerbations of the autoimmune disease systemic lupus erythematosus (SLE) in humans has been investigated in …
The use of the murine chronic graft vs host (CGVH) disease, a
Studies were conducted to evaluate the use of a murine SLE-like disease for the discovery of novel drugs: This disease is the result of a chronic form of a graft vs host (GVH) reaction. …
Secondary Heavy Chain Rearrangement - PubMed Central (PMC)
The chronic graft-versus-host (cGVH) model of SLE is produced by the transfer of allogeneic T cells into normal mice. Donor helper T cells react against incompatible host class II structures …
ApoE 缺陷狼疮小鼠模型中加速动脉粥样硬化。,Clinical …
2008年3月5日 · 系统性红斑狼疮 (sle) 患者中动脉粥样硬化的加速发展与心血管疾病风险的增加尚不清楚。 一个合适的小鼠模型将极大地有助于理解这种关联的机制。 因此，我们将动脉粥样 …
Modulation of Autoimmunity by TLR9 in the Chronic Graft-vs-Host …
2006年11月15日 · Previous work showed that the murine chronic graft-vs-host (cGVH) syndrome is a useful system to probe the mechanisms of tolerance loss in SLE B cells . In this model, …
Accelerated atherosclerosis in ApoE deficient lupus mouse models
2008年5月1日 · We tested three different SLE models. The cGVH had the advantage of providing an excellent control group, as did the B6/lpr model. The MRL/lpr model gets the most severe …
B cells require "nurturing" by CD4 T cells during development
The murine chronic GVH (cGVH) model of SLE is induced by allo-recognition of foreign major histocompatibility complex (MHC) class II determinants. Previous studies have shown that …
Mature B cells preferentially lose tolerance in the chronic graft ...
2007年10月15日 · Chronic graft-vs-host (cGVH) disease is a well-characterized systemic lupus erythematosus (SLE) model. Induction of cGVH in anti-DNA H chain knockin (3H9KI) …
CD74 deficiency mitigates systemic lupus erythematosus-like ...
CD74 deficiency also mitigates SLE-like autoimmunity and pathology in cGVH mice. Like the Fas lpr mice, B6 mice injected intraperitoneally with bm12 splenocytes develop cGVH manifested …
B-cells require “nurturing” by CD4 T cells during development in …
The murine chronic GVH (cGVH) model of SLE is induced by allo-recognition of foreign major histocompatibility complex (MHC) Class II determinants. Previous studies have shown that …