A spontaneous mutation in <em>Tlr4</em> occurred in C3H/HeJ at the lipopolysaccharide response locus (mutation in toll-like receptor 4 gene, <em>Tlr4^Lps-d</em>) making C3H/HeJ mice more resistant to endotoxin. C3H/HeJ mice are highly susceptible to infection by Gram-negative bacteria such as Salmonella enterica.

C3H/HeJ 小鼠的共显性 Lps d 等位基因显示对应于 Toll 样受体 4 基因 ( Tlr4 )的第三个外显子中的错义突变，预测将在多肽链的第 712 位用组氨酸替换脯氨酸。 一、来源. 1920年，Strong（Leonell C. Strong）采用 Bagg白化小鼠 （Bagg albino）的雌性A小鼠（雌小鼠8号）与 Little （C.C. Little）培育的近交系雄性 DBA小鼠 （雄性1号）交配产生的杂交小鼠（C小鼠）。 接下来为了获得自发性肿瘤发生率不同的近交小鼠，Strong将C小鼠进行了选择性地部分近交（partially …

C3H小鼠是引进用于医学研究，感觉神经研究、 免疫学 和炎症研究的小鼠。 [1] 1920年Strong将一只Bagg albino雌鼠和一只DBA雄鼠进行杂交得到该品系，1930年Andervont引入了该品系的4只雌性和2只雄性鼠，随后Heston引入了第35代，1951年NIH从Heston引入第57代，1974年Charles River从NIH引入并于1975年进行了 剖腹产，2001年维通利华从Charles River引入该品系。 [2] 该品系为视网膜变性1 (Pde6brd1)基因突变的纯合子，在断奶期失明。 同时，C3H小鼠有很高的 …

在C小鼠近交到第8代（F8)时，将F8小鼠中5635号雄性选入近交，通过培育和筛选，形成了两个亚系近交小鼠： C3H/st亚系 小鼠，该雌性小鼠的乳腺肿瘤发生率高达90%以上；以及 CBA/st亚系 小鼠，该小鼠乳腺肿瘤发生率低、寿命长。 C3H中的H=high tumor family （HTF）。 注意： （1)C3H小鼠的原种与Bagg白化小鼠有区别. A小鼠来自Strong对Bagg白化雌性小鼠进行近交期间产生的雌性小鼠，而不是使用Bagg（Halsey J. Bagg）那里得到的原种白化小鼠。 （2) C3H …

C3H mice are known for their aggressive behavior and hyperactivity. They display increased anxiety-like behavior and tend to avoid open spaces. C3H mice also notable for their cognitive abilities, especially in learning and memory tasks, making them an ideal model organism for studying cognitive disorders and the effects of drugs that affect ...

C3H/HeJ 小鼠通常称为 C3H 小鼠，作为一种常规品系广泛用于多种研究领域，包括癌症、传染病、感觉神经和心血管生物学研究。 C3H/HeJ 品系的脂多糖应答位点上发生 Tlr4 自发突变（toll 样受体 4 基因突变， Tlr4 Lps-d），使C3H/HeJ小鼠对内毒素具有更高的耐受性。 C3H/HeJ小鼠对革兰氏阴性菌（如肠沙门氏菌）高度易感。 杰克森实验室提供的C3H亚系为视网膜变性1基因 (Pde6b rd1) 突变的纯合小鼠，该突变会造成小鼠在离乳期失明。 重点提示: 此品系小鼠不携带小鼠乳腺 …

The C3H inbred model was developed by Strong et al. in 1920 by intercrossing a Bagg albino female mouse to a DBA male mouse. Andervont received stock from Strong in 1930. Heston received stock at F35 from Andervont.

Mice inoculated at age 3 weeks also developed polyarthritis, but severity was reduced when inoculated as adults. Carditis was also common (Barthold et al 1990), and mice were susceptible to the development of arthritis (contrast BALB/c) (Matyniak and Reiner, 1995).

C3H小鼠是由白化小鼠与DBA小鼠杂交后经过选择性近交而成的品系，具有自发性形成乳腺肿瘤、肝脏肿瘤和视网膜变性的特点。 C3H小鼠又分为若干不同亚系，C3H/An mouse,C3H/He mouse,C3H/Bi mouse,C3H/HeJ mouse，不同品系之间差别明显。

C3H/HeN mice are used in a wide range of studies. They are homozygous for the Pde6brd1 allele and have an early onset severe retinal degeneration that causes blindness at weaning age.