Checkpoint kinases (Chks) are protein kinases that are involved in cell cycle control. Two checkpoint kinase subtypes have been identified, Chk1 and Chk2. Chk1 is a central component of genome surveillance pathways and is a key regulator of the cell cycle and cell survival.

2024年12月24日 · CHEK1 (Checkpoint Kinase 1) is a Protein Coding gene. Diseases associated with CHEK1 include Oocyte/Zygote/Embryo Maturation Arrest 21 and Lynch Syndrome 2. Among its related pathways are HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) and Regulation of activated PAK-2p34 by proteasome mediated degradation.

DNA damage induces activation of Chk1, which then transduces the checkpoint signal and facilitates cell cycle arrest and DNA damage repair. Significant progress has been made recently towards our understanding of Chk1 regulation and its implications in cancer etiology and therapy.

该基因编码的蛋白质属于 Ser/Thr 蛋白激酶家族。 它是检查点介导的细胞周期停滞所必需的，以响应 DNA 损伤或未复制 DNA 的存在。 该蛋白用于整合来自 ATM 和 ATR 的信号，这两种细胞周期蛋白参与 DNA 损伤反应，也与减数分裂前期 I 中的染色质相关。 细胞需要通过该蛋白磷酸化 CDC25A 蛋白磷酸酶以延迟细胞周期进程以响应到双链 DNA 断裂。 已发现该基因的几种可变剪接转录物变体。 [RefSeq 提供，2011 年 10 月] The protein encoded by this gene belongs to …

CHEK1，别名CHK1、OZEMA21，是一种由人类基因编码的Ser/Thr蛋白激酶家族成员，对响应DNA损伤或未复制DNA存在的检查点调节细胞周期停滞至关重要。 CHEK1可整合来自ATM和ATR两种参与DNA损伤应答的细胞周期蛋白的信号，这些蛋白在减数分裂前期I中也与染色质相关。 CHEK1对CDC25A蛋白磷酸酶的磷酸化是必需的，以使细胞响应双链DNA断裂而延迟细胞周期进程。 CHEK1参与DNA损伤检查点信号传导、G2/M转换的有丝分裂细胞周期以及内细胞团细胞增 …

2021年1月28日 · A critical component of this response is the serine/threonine kinase CHK1 which is encoded by the CHEK1 gene. Originally identified as a regulator of the G2/M checkpoint, CHK1 has since been shown to play important roles in DNA replication, mitotic progression, DNA repair, and overall cell cycle regulation.

Enables histone kinase activity (H3-T11 specific). Involved in epigenetic maintenance of chromatin in transcription-competent conformation; regulation of histone H3-K9 acetylation; and regulation of transcription from RNA polymerase II promoter in response to …

CHEK1: a hub gene related to poor prognosis for lung adenocarcinoma. Maternal heterozygous mutation in CHEK1 leads to mitotic arrest in human zygotes. Targeting CDC7 potentiates ATR-CHK1 signaling inhibition through induction of DNA replication stress in liver cancer.

Checkpoint kinase 1 (CHEK1) is a gene that encodes a protein that is a member of the serine/threonine kinase family. The protein functions in the cell cycle arrest response to DNA damage or unreplicated DNA.

2019年6月17日 · Our results uncover CHEK1 as the most promising target for HNSCC. CHEK1 expression is essential across a panel of HNSCC cell lines but redundant for growth and survival of untransformed oral...