Chemerin is a chemoattractant protein that acts as a ligand for the G protein-coupled receptor CMKLR1 (also known as ChemR23). Chemerin is a 14 kDa protein secreted in an inactive form as prochemerin and is activated through cleavage of the C-terminus by inflammatory and coagulation serine proteases .

Chemerin, encoded by the gene Rarres2, is a newly discovered adipokine involved in inflammation, adipogenesis, angiogenesis and energy metabolism. In humans, local and circulating levels of chemerin are positively correlated with BMI and obesity-related biomarkers.

进一步研究表明，Chemerin 通过其受体ChemR23 介导线粒体活性氧的产生，激活腺苷酸活化蛋白激酶(AMPKa)， 抑制哺乳动物雷帕霉素靶蛋白(mTOR)的活性，从而调控自噬相应蛋白的表达。

表 1 Chemerin与 HEK-huCCRL2 的结合概况. 通过 SPRM，可以对一种以前未报道过的 C-C 趋化因子进行直接结合和动力学分析。研究人员测定了 Chemerin 与 HEK 293T 亲本细胞以及 HEKhuCCRL2 变体细胞上的 CCRL2 的结合动力学。 CCRL2 不激活细胞内的 G 蛋白，而是将配体集中在质膜上 ...

Chemerin, encoded by the gene retinoic acid receptor responder 2 (Rarres2), also known as tazarotene-induced gene 2 (TIG2), was recently identified as one of the adipokines with autocrine, paracrine and even endocrine roles in vivo (Rourke et al. 2013).

Chemerin (RARRES2 or TIG2) is a recently discovered chemoattractant protein that serves as a ligand for the G protein-coupled receptor CMKLR1 (ChemR23 or DEZ) and has a role in adaptive and innate immunity.

2022年8月7日 · As a multifaceted adipokine, chemerin has been found to perform functions vital for immunity, adiposity, and metabolism through its three known receptors (chemokine-like receptor 1, CMKLR1; G-protein-coupled receptor 1, GPR1; C …

Chemerin(趋化素)是新发现的脂肪细胞因子,它可由脂肪细胞分泌,通过自分泌途径作用于自身受体CMKLR1,促进脂肪细胞分化及葡萄糖转运,并可通过旁分泌途径作用于炎性反应细胞(如巨噬细胞).从而对脂肪组织及脂质代谢产生一系列影响,提示chemerin可能在肥胖及胰岛素 ...

Chemerin是一种由脂肪细胞分泌的脂肪因子，在白色脂肪组织中高表达，以自分泌/旁分泌的方式发挥生物学作用，与肥胖、胰岛素抵抗和代谢综合征有关。近年来，Chemerin因其在不同器官和系统，如代谢、炎症和癌症等中发生控制中的多重作用而引起了特别的关注。

Chemerin是新发现的脂肪因子,它主要以自分泌或旁分泌的形式由脂肪组织分泌。Chemerin可通过与其受体结合,募集炎性细胞,调节胰岛素的敏感性和脂肪细胞分化,从而对糖脂代谢产生影响。因此,Chemerin可能在肥胖及代谢综合征中起重要作用。