为了给大家做知识整理，就临时搜索了一个最新（2022年9月发表在NC杂志）的文献：《Single cell atlas identifies lipid-processing and immunomodulatory endothelial cells in healthy and malignant breast》，因为文章的重点就是内皮细胞，所以推荐大家仔细阅读哦。 文章里面把内皮细胞主要是区分成为了淋巴内皮和血管内皮， 其中血管可以细分为动脉静脉和毛细血管： lymphatic ECs (LECs; CCL21, PROX1). 如下所示，可以看到淋巴内皮和其它各种各样的血管 …

2024年12月24日 · CA4 (Carbonic Anhydrase 4) is a Protein Coding gene. Diseases associated with CA4 include Retinitis Pigmentosa 17 and Retinitis Pigmentosa. Among its related pathways are Erythrocytes take up carbon dioxide and release oxygen and Metabolism. Gene Ontology (GO) annotations related to this gene include carbonate dehydratase activity.

Clinical resource with information about CA4, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.

该基因编码的蛋白可启动碳酸盐脱水酶活性。 预计参与碳酸氢盐运输和一碳代谢过程。 预计在二氧化碳运输和 pH 调节的上游或内部起作用。 位于膜内。 是质膜的锚定成分。 在心血管系统中表达；泌尿生殖系统；神经系统;和尾巴。 该基因的人类直系同源物与色素性视网膜炎有关。 与人 CA4（碳酸酐酶 4）同源。 [由基因组资源联盟提供，2022 年 4 月] Enables carbonate dehydratase activity. Predicted to be involved in bicarbonate transport and one-carbon …

碳酐酶（CAs）是一类大型锌金属酶家族，能催化二氧化碳的可逆水合作用。 它们参与多种生物过程，包括呼吸、钙化、酸碱平衡、骨吸收和房水、脑脊髓液、唾液和胃酸的形成。 它们在组织分布和亚细胞定位方面表现出广泛的多样性。 该基因编码一种糖磷脂酰肌醇锚定的膜异构酶，表达在肺（和其他某些）毛细血管和肾小管的近端表面。 其确切功能尚不清楚；然而，它可能参与遗传性碳酸氢盐转运异常。 [由RefSeq，2008年7月提供] Dir./Indir. Mutations in the gene encoding …

Conclusions: Our study revealed that CA4 was a potential biomarker for aggressive progression and poor prognosis in KIRC, LGG, LUAD, PRAD and UVM, correlated with immune infiltration in various tumor environments. These results suggested that CA4 possibly served as a promising prognostic and immune infiltration biomarker in many cancers.

使用针对观察到的Csa3Sso·cA4结构界面的Csa3Sso突变体的cA4结合亲和力分析，我们鉴定了与更广泛保守的cOA结合CARF基序不同的Csa3特异性cA4结合基序。

CA4的详细信息，包括基因名称，代码，染色体位置，相互作用关系和通路，简述为碳酸酐酶（CA）的是一个大家族催化二氧化碳可逆的水化锌金属酶。

Learn about the CA4 gene, its role in calcium signaling, mutations associated with diseases, and latest research advancements. Explore resources and find answers to your questions.

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