Chiou Mee Kong's 12 research works with 227 citations and 729 reads, including: The use of transformed IMR90 cell model to identify the potential extra-telomeric effects of hTERT in...

2013年5月6日 · Short or dysfunctional telomeres are often recognized as DNA DSBs, triggering cell-cycle arrest and result in cellular senescence or apoptotic cell death. Therefore, telomere shortening serves as an important tumor-suppressive mechanism by limiting cellular proliferative capacity by regulating senescence checkpoint activation.

Human telomerase reverse transcriptase (hTERT), the catalytic subunit of telomesase, is responsible for telomere maintenance and its reactivation is implicated in almost 90% human cancers. Recent evidences show that hTERT is essential for neoplastic transformation independent of its canonical function.

2013年2月13日 · Here, we report our observations that all randomly picked induced pluripotent cancer cells (iPCs) established previously do not possess mutations known in the parental population. This unanticipated observation is most parsimoniously explained by the Elite model, whereby putative early tumor progenies were selected during induction to pluripotency.

We studied WJ mesenchymal stem cells (hWJSCs) from UC from mothers without GDM (Normal; n = 3); insulin-controlled GDM mothers (GDMi; n = 3) and diet-controlled GDM mothers (GDMd; n = 3)].

Short or dysfunctional telomeres are often recognized as DNA DSBs, triggering cell-cycle arrest and result in cellular senescence or apoptotic cell death. Therefore, telomere shortening serves as an important tumor-suppressive mechanism by limiting cellular proliferative capacity by regulating senescence checkpoint activation.

Kong, Chiou Mee，现任职于新加坡国立大学，曾任职于国家大学卫生系统机构，个人H指数为5，累计发表论文7篇，论文总被引数累计167次，主要研究方向涵盖生物化学,遗传学和分子生物学、综合性学科、免疫学与微生物学等领域，在FEBS Journal、Stem Cell Reviews and Reports ...

Semantic Scholar profile for Kong Chiou Mee, with 1 highly influential citations and 1 scientific research papers.

2013年5月8日 · Short or dysfunctional telomeres are often recognized as DNA DSBs, triggering cell-cycle arrest and result in cellular senescence or apoptotic cell death. Therefore, telomere shortening serves as an important tumor-suppressive mechanism by limiting cellular proliferative capacity by regulating senescence checkpoint activation.

2020年8月1日 · In the present study, we aimed to generate iPSCs from hWJSCs isolated from human umbilical cords of normal and GDM pregnancies. The resulting hWJSC-iPSCs were homogeneous and displayed human embryonic stem cells (hESCs)-like characteristics and readily differentiated into multiple lineages in vitro and in vivo.