2024年12月24日 · CHKA (Choline Kinase Alpha) is a Protein Coding gene. Diseases associated with CHKA include Neurodevelopmental Disorder With Microcephaly, Movement Abnormalities, And Seizures and Autosomal Recessive Non-Syndromic Intellectual Disability .

Choline kinase alpha is an enzyme that in humans is encoded by the CHKA gene. [5] [6] [7] The major pathway for the biosynthesis of phosphatidylcholine occurs via the CDP-choline pathway. The protein encoded by this gene is the initial enzyme in …

关于 chka Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:68,052,859-68,121,388 (from NCBI) This gene has 8 transcripts (splice variants), 206 orthologues and 3 paralogues.

2025年1月4日 · Results indicate that choline kinase alpha (CHKA) contributes to tumor progression and metastasis and may serve as a prognostic biomarker and potential therapeutic target in colorectal carcinoma (CRC).

胆碱激酶α隶属于胆碱激酶蛋白家族,是cdp-胆碱通路的关键酶。在多种人类肿瘤组织中均发现有胆碱激酶α表达升高,如乳腺癌、结直肠癌、前列腺癌、肺癌等。研究已证实胆碱激酶α与多种肿瘤相关通路存在交互作用。由于其在肿瘤组织中的高表达和异常激活,胆碱激酶α可能是有助于肿瘤诊断的 …

Results indicate that choline kinase alpha (CHKA) contributes to tumor progression and metastasis and may serve as a prognostic biomarker and potential therapeutic target in colorectal carcinoma (CRC).

作为磷脂酰胆碱（pc）生物合成途径中的第一个关键酶——胆碱激酶α(chka)是这些变化的一个重要媒介，并已被证实在数种癌症组织中存在高表达和异常激活，这使得其可能成为一种有助于肿瘤诊断的分子标志物，并成为肿瘤治疗的新靶点。

2017年2月1日 · Choline Kinase consists of three isoforms, CHKα1, CHKα2 and CHKβ, encoded by two separate genes (CHKA(Human)/Chka(Mouse) and CHKB(Human)/Chkb(Mouse)). Both isoforms have similar structures and enzyme activity, but display some distinct molecular structural domains and differential tissue expression patterns.

2025年2月1日 · While Choline Kinase Alpha (CHKA) has been implicated in promoting various types of tumors, its specific role in glioma pathogenesis remains unclear. Our study initially demonstrates that CHKA enhances the proliferation, migration, and invasion abilities of glioma cells. Interestingly, CHKA also stimulates the release of exosomes from glioma cells.

Choline kinase α (CHKα) plays a crucial role in the regulation of membrane phospholipid synthesis and has oncogenic properties in vitro. We have analyzed the expression of CHKα in cell lines derived from pancreatic ductal adenocarcinoma (PDAC) and have found increased CHKα expression, associated with differentiation.