Impact of Cholesterol Metabolism in Immune Cell Function and ...
In this review, we describe the main regulatory pathways and mechanisms of cholesterol metabolism and how these affect immune cell generation, proliferation, activation, and …
The Cholesterol Pathway: Impact on Immunity and Cancer
Cholesterol is a multifaceted metabolite known to modulate processes in cancer, atherosclerosis, and autoimmunity. A common denominator between these diseases appears to be the …
Cholesterol, inflammation and innate immunity - PMC
Hypercholesterolaemia leads to cholesterol accumulation in macrophages and other immune cells, which promotes inflammatory responses, including augmentation of Toll-like receptor …
Cholesterol Metabolism and Immunity | New England Journal of …
2014年11月13日 · Research from both the bench and the clinic has provided increasing evidence for cross-talk between cholesterol metabolism and the immune system, providing a greater …
Cholesterol sensing and metabolic adaptation in tissue immunity
2024年10月17日 · Immune cell function is highly regulated by cell-autonomous cholesterol metabolism; in turn, secretion of cholesterol-derived metabolites by stromal and immune cells …
Cholesterol mobilization regulates dendritic cell maturation and …
4 天之前 · In this comparison of mature cDCs with cDC1 and cDC2 cells, we could still identify an mRNA signature of cholesterol metabolism, largely dominated by genes encoding enzymes for …
Cholesterol Metabolism - an overview | ScienceDirect Topics
Depicted are key immunomodulatory roles of the cholesterol pathway in mammalian adaptive and innate immunity. Cholesterol can impact the T cell receptor (TCR) by direct binding or through …
SMPDL3A links cholesterol metabolism to the cGAS-STING …
2023年11月14日 · In this issue of Immunity, Hou et al. demonstrate that LXR signaling induces SMPDL3A, a cGAMP-degrading enzyme that restricts cGAS-cGAMP-STING innate immune …
Dietary cholesterol metabolite regulation of tissue immune cell ...
2022年8月8日 · Diet cholesterol byproducts are now known to regulate function and migration of diverse immune cell subsets in tissues. The hydroxylated metabolites of cholesterol oxysterols …
Dietary Cholesterol Metabolite Regulation of Tissue Immune Cell ...
2022年8月15日 · Diet cholesterol by-products are now known to regulate function and migration of diverse immune cell subsets in tissues. The hydroxylated metabolites of cholesterol oxysterols …
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