Fat and cholesterol arriving at the liver are repackaged into VLDLs. 2. VLDLs enter the bloodstream between meals and travel to the peripheral tissues. 3. VLDLs meet tissues expressing lipoprotein lipase (e.g. muscle and adipose tissue) and release their glycerol and fatty acids.

In the capillaries of adipose and muscle tissue, apoprotein C-II (apo C-II) on the chylomicron activates endothelial lipoprotein lipase (LPL) to convert 90% of chylomicron triglyceride to fatty acids and glycerol, which are taken up by adipocytes and muscle cells for energy use or storage.