A substance (or ligand) is cholinergic if it is capable of producing, altering, or releasing acetylcholine, or butyrylcholine ("indirect-acting"), or mimicking their behaviours at one or more of the body's acetylcholine receptor ("direct-acting") or butyrylcholine receptor types ("direct-acting").

Several agonists, antagonists, and inhibitors have been developed to target the cholinergic system to control inflammation in different tissues. This review discusses how various molecules of the neuronal and non-neuronal cholinergic system (NNCS) interact with the immune cells.

2019年10月4日 · In the central nervous system, cholinergic activity is related to arousal, awareness, learning, memory, attention and reward, among others. Not surprisingly, abnormal cholinergic transmission has been associated with Alzheimer’s disease, a neurodegenerative condition characterized by memory loss.

Cholinergic neurons provide the primary source of acetylcholine to the cerebral cortex, and promote cortical activation during both wakefulness and rapid eye movement sleep. [1] The cholinergic system of neurons has been a main focus of research in aging and neural degradation, specifically as it relates to Alzheimer's disease. [2]

The cholinergic system is a key modulatory pathway of both the central and peripheral nervous systems because acetylcholine synthesized and released by cholinergic neurons and non-neuronal cells regulates numerous physiological functions.

The cholinergic system is composed of organized nerve cells that use the neurotransmitter acetylcholine in the transduction of action potentials. These nerve cells are activated by or contain and release acetylcholine during the propagation of a nerve impulse.

2023年8月14日 · Cholinergic receptors function in signal transduction of the somatic and autonomic nervous systems. The receptors are named because they become activated by the ligand acetylcholine. These receptors subdivide into nicotinic and muscarinic receptors, which are named secondary to separate activating ligands that contributed to their study.

The cholinergic system is composed of metabotropic muscarinic and ionotropic nicotinic cholinergic receptors, vesicular acetylcholine transporter (VAChT), choline transporter (CHT), choline acetyltransferase (ChAT), acetylcholinesterase (AChE), and butyrylcholinesterase (BuChE) enzymes, and acetylcholine (ACh) as the principal neurotransmitter ...

The present work enlightens cholinergic system which refers to those receptors which respond to the transmitter acetylcholine and are mostly parasympathetic. There are two types of cholinergic receptors, classified according to which, either they are stimulated by …

Within the brain, major cholinergic projection pathways from the basal forebrain and the brainstem support these centrally mediated processes, and dysregulation of the cholinergic system is implicated in cognitive decline associated with aging and …