2024年12月24日 · DDIT3 (DNA Damage Inducible Transcript 3) is a Protein Coding gene. Diseases associated with DDIT3 include Myxoid Liposarcoma and Soft Tissue Sarcoma. Among its related pathways are Gene expression (Transcription) and Unfolded Protein Response (UPR).

DNA damage-inducible transcript 3, also known as C/EBP homologous protein (CHOP), is a pro- apoptotic transcription factor that is encoded by the DDIT3 gene. [5][6] It is a member of the CCAAT/enhancer-binding protein (C/EBP) family of DNA-binding transcription factors. [6] .

2019年1月4日 · CHOP plays an important role in ER stress-induced apoptosis and this review focuses on its multifunctional roles in that process, as well as its role in apoptosis during microbial infection. We summarize the upstream and downstream pathways of CHOP in …

CHOP belongs to the family of CCAAT/enhancer binding proteins (C/EBPs) and is involved in the regulation of genes that encode proteins involved in proliferation, differentiation and expression, and energy metabolism. CHOP is a 29 kD protein with …

FUS-CHOP, a hallmark fusion gene in mixoid liposarcoma, has an instructive role in cell lineage commitment. pharmacological inhibition of ChoKalpha induces cancer cell death through a mechanism that involves the activation of exaggerated and persistent ER stress supported by CHOP overproduction.

2003年12月19日 · One of the components of the ER stress-mediated apoptosis pathway is C/EBP homologous protein (CHOP), also known as growth arrest- and DNA damage-inducible gene 153 (GADD153).

2000年12月12日 · The transcription factor CHOP/GADD153 gene is induced by cellular stress and is involved in mediating apoptosis. We report the identification of a conserved region in the promoter of the CHOP gene responsible for its inducibility by endoplasmic reticulum (ER) stress.

GADD153/CHOP (growth arrest and DNA damage -inducible gene 153 / C/EBP homology protein)是一种细胞应激相关蛋白,又称C/EBPξ,DNA damage in-ducible transcript 3 ( DDIT3 ),属于C/EBP (CCAAT/enhancer binding proteins)家族成员,对细胞增生及分化具有十分重要的作用. 百度学术集成海量学术资源，融合人工智能、深度学习、大数据分析等技术，为科研工作者提供全面快捷的学术服务。 在这里我们保持学习的态度，不忘初心，砥砺前行。

2006年1月23日 · CHOP (GADD153) is a protein of the C/EBP family of transcriptional regulators, which dimerizes with other C/EBP members and changes their DNA-binding and transactivation properties. It induces...

2018年1月1日 · CHOP, also known as growth arrest and DNA damage-inducible gene 153 (GADD153), DNA–damage-inducible transcript 3 (DDIT3) and C/EBP ζ, is a 29 kDa protein consisting of 169 (human) or 168 (rodents) amino acid residues. CHOP was first identified on the basis of DNA-damage-induced growth arrest.