2024年12月24日 · CHRNA6 (Cholinergic Receptor Nicotinic Alpha 6 Subunit) is a Protein Coding gene. Diseases associated with CHRNA6 include Alcohol Dependence and Dystonia 6, Torsion. Among its related pathways are Postsynaptic nicotinic acetylcholine receptors and Transmission across Chemical Synapses.

Chrna6 has a cellular expression signature for retinal ganglion cells with high correlation to Thy1, a known marker. Immunofluorescence confirms this gene is preferentially expressed by RGCs in the young and adult mouse retina and expression is reduced in glaucoma.

2024年9月26日 · Our findings indicate that the CHRNA6 may act as a predictive indicator for SCLC patients receiving immunotherapy. The study also uncovers the aberrant expression of CHRNA6 in a range of human cancers and its potential roles in immunology and prognosis, offering novel perspectives for tailored cance …

2025年1月14日 · Human genetic variations in CHRNA6, encoding for the α6 subunit, have been linked to smoking and alcohol in some instances and support further investigation of the role of these receptor subunits in alcohol use and vulnerability.

Clinical resource with information about CHRNA6, Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior., and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.

2010年5月18日 · CHRNA6 is 1 of several subunits that can be incorporated into 5-subunit nicotinic acetylcholine receptors (nAChRs), which function as ligand-gated ion channels involved in fast synaptic transmission (Ebihara et al., 2002).

CHRNA6 may be associated with immune infiltration in LUSC and affects patient prognosis and immunotherapeutic response by regulating immune cells and immune pathways. In addition, adavosertib may be a potential drug for the treatment of LUSC.

Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.

2025年2月8日 · Enables acetylcholine-gated monoatomic cation-selective channel activity. Involved in presynaptic modulation of chemical synaptic transmission. Acts upstream of or within membrane depolarization and regulation of dopamine secretion. Part of acetylcholine-gated channel complex.

Description: Homo sapiens cholinergic receptor nicotinic alpha 6 subunit (CHRNA6), transcript variant 1, mRNA. (from RefSeq NM_004198) RefSeq Summary (NM_004198): This gene encodes an alpha subunit of neuronal nicotinic acetylcholine receptors. These receptors consist of five subunits and function as ion channels involved in neurotransmission.