2024年12月24日 · CHRNB2 (Cholinergic Receptor Nicotinic Beta 2 Subunit) is a Protein Coding gene. Diseases associated with CHRNB2 include Epilepsy, Nocturnal Frontal Lobe, 3 and Autosomal Dominant Nocturnal Frontal Lobe Epilepsy. Among its related pathways are Postsynaptic nicotinic acetylcholine receptors and Transmission across Chemical Synapses.

Neuronal acetylcholine receptors are homo- or heteropentameric complexes composed of homologous alpha and beta subunits. They belong to a superfamily of ligand-gated ion channels which allow the flow of sodium and potassium across the plasma membrane in response to ligands such as acetylcholine and nicotine.

神经元乙酰胆碱受体是由同源的α和β亚基组成的同源或异源五聚体复合物。 它们属于配体门控离子通道超家族，允许钠和钾响应配体 (如乙酰胆碱和尼古丁) 流过质膜。 该基因编码几个 β 亚基之一。 该基因的突变与常染色体显性遗传性夜间额叶癫痫有关。 [RefSeq 提供，2008 年 7 月] Neuronal acetylcholine receptors are homo- or heteropentameric complexes composed of homologous alpha and beta subunits.

The CHRNB2 gene provides instructions for making one part (subunit) of a larger protein called a neuronal nicotinic acetylcholine receptor (nAChR). Learn about this gene and related health conditions.

CHRNB2 is a logical candidate for influencing smoking behavior and nicotine dependence; Mutations of the gene encoding CHRNB2 may be linked to nocturnal frontal lobe epilepsy. Our present study provided the first line of direct evidence suggesting that the CHRNA4 gene combined with CHRNB2 receptor gene may be linked to schizophrenia.

2018年9月7日 · HGNC Approved Gene Symbol: CHRNB2. Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38) : 1:154,567,778-154,580,013 (from NCBI) The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses.

此基因的人类同源物与常染色体显性夜间额叶癫痫和常染色体显性夜间额叶癫痫3有关。 与人类CHRNB2（胆碱能受体烟碱β2亚单位）正交。 [由基因组资源联盟，2022年4月提供] 该基因暂未发现相关的转录本和蛋白质序列信息。 A tissue-specific atlas of mouse protein phosphorylation and expression. Lineage-specific biology revealed by a finished genome assembly of the mouse.

chrnb2 基因产物： 烟碱型乙酰胆碱受体亚单位β2。 蛋白功能： 神经元烟碱型乙酰胆碱能受体的其中一个亚单位，属于配体门控的离子通道，乙酰胆碱结合后可导致跨膜离子传导通道的开放。

用于研究注意力缺陷多动障碍；自闭症谱系障碍；和常染色体显性夜间前额叶癫痫3。这个基因的人类同源物与常染色体显性夜间前额叶癫痫和常染色体显性夜间前额叶癫痫3有关。与人类chrnb2（胆碱能受体烟碱β2亚单位）正交。[由基因组资源联盟，2022年4月提供]

Enables acetylcholine binding activity; acetylcholine-gated cation-selective channel activity; and quaternary ammonium group binding activity. Contributes to heterocyclic compound binding activity. Involved in acetylcholine receptor signaling pathway; cholinergic synaptic transmission; and response to nicotine. Located in plasma membrane raft.