Baculoviral IAP repeat-containing protein3 (also known as cIAP2) is a protein that in humans is encoded by the BIRC3 gene. [5] [6] cIAP2 is a member of the inhibitor of apoptosis family that inhibit apoptosis by interfering with the activation of caspases.

We demonstrate here that cIAP2 −/− mice exhibit profound resistance to lipopolysaccharide (LPS)-induced sepsis, specifically because of an attenuated inflammatory response. We show that LPS potently upregulates cIAP2 in macrophages and that cIAP2 −/− macrophages are highly susceptible to apoptosis in a LPS-induced proinflammatory environment.

2022年6月19日 · It is well-documented that the cellular inhibitor of apoptosis 2 (cIAP2) is induced by inflammatory stimuli and regulates adaptive and innate immune responses, cell death, and the production of inflammatory mediators. However, the impact of cIAP2 on neuroinflammation associated with MS and disease severity remains unknown.

凋亡抑制蛋白（inhibitor of apoptosis protein，IAP）是一类抑制细胞内源性凋亡的蛋白家族，在结构上具有同源性。 在人类，目前发现的成员有8种，包括XIAP、NAIP、cIAP1、cIAP2、ILP2、Apollon、Livin、Survivin。 XIAP（X-linked IAP，X连锁凋亡抑制蛋白）的 N 端主要有 3 个 IAP 重复序列 BIR1~BIR3，C端主要有一个 RING 锌指样结构域，具有 E3 泛素连接酶活性。 BIR 结构域和 RING 锌指结构域是 IAP 家族成员的共有结构，也是 XIAP 抗调亡的重要结构。 XIAP 是惟 …

2022年6月19日 · It is well-documented that the cellular inhibitor of apoptosis 2 (cIAP2) is induced by inflammatory stimuli and regulates adaptive and innate immune responses, cell death, and the production of inflammatory mediators. However, the impact of cIAP2 on neuroinflammation associated with MS and disease severity remains unknown.

2014年12月11日 · We propose that the different caspase-3 functions in microglia, and potentially other cell types, reside in the active caspase-3 complexes formed. These results also could indicate cIAP2 as a...

Here we report that the cIAPs are critical effectors of the inflammasome and are required for efficient caspase-1 activation. cIAP1, cIAP2, and the adaptor protein TRAF2 interacted with caspase-1-containing complexes and mediated the activating nondegradative K63-linked polyubiquitination of caspase-1.

2012年2月14日 · Cellular inhibitor of apoptosis protein 2 (cIAP2) is a potent suppressor of apoptotic cell death. We have shown previously that cIAP2 is involved in the tumor necrosis factor alpha (TNF-α)-induced anti-hepatitis B virus (HBV) response; however, the mechanism for this antiviral effect remains unclear.

2019年5月28日 · Cellular inhibitor of apoptosis proteins cIAP1 and cIAP2 ubiquitinate nuclear factor κB (NF-κB)-inducing kinase (NIK) to suppress non-canonical NF-κB signaling and substrates such as receptor interacting protein kinase 1 (RIPK1) to promote cell survival. We investigate how these functions contribute …

2019年5月28日 · Cellular inhibitor of apoptosis proteins cIAP1 and cIAP2 ubiquitinate nuclear factor κB (NF-κB)-inducing kinase (NIK) to suppress non-canonical NF-κB signaling and substrates such as receptor interacting protein kinase 1 (RIPK1) to promote cell survival.