Dec 24, 2024 · CIROP (Ciliated Left-Right Organizer Metallopeptidase) is a Protein Coding gene. Diseases associated with CIROP include Heterotaxy, Visceral, 12, Autosomal and Visceral Heterotaxy.

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Ciliated left-right organizer metallopeptidase (CIROP) is a protein that in humans is encoded by the CIROP gene. [1] The CIROP gene is found on the negative strand of the long arm of human chromosome 14 at position 11.2.

Nov 23, 2023 · Discovery of a genetic module essential for assigning left-right asymmetry in humans and ancestral vertebrates. Szenker-Ravi E, et al. Nat Genet, 2022 Jan. PMID 34903892. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24.

CIROP encodes a putative zinc-dependent peptidase that is expressed during the development of the left-right organizer (LRO), a transient epithelial organ that establishes asymmetry in the embryo (Szenker-Ravi et al., 2022).

Gene ID: 100128908, updated on 8-Feb-2025. Predicted to enable peptidase activity. Predicted to be involved in establishment of left/right asymmetry. Predicted to be located in membrane. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Feb 2025]

Dec 13, 2021 · Through phylogenetic analyses, we uncovered a hitherto uncharacterized metalloprotease, which we named CIROP. Like MMP21 and three other genes, namely PKD1L1, DAND5 and C1orf127, we find that...

关于 cirop Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:23,099,062-23,104,989 (from NCBI) This gene has 4 transcripts (splice variants), 54 orthologues and is associated with 1 phenotype.

脊椎动物胚胎发育过程中，有一个称为 left-right organizer (LRO) 的短暂存在的器官，它决定脊椎动物左右对称轴的形成。 在 LRO 中，运动纤毛可以打破两侧对称性，在鱼类、两栖类、啮齿类和人类中，LRO 都有运动纤毛；而在鸟类、爬行类、偶蹄类、鲸类中则没有运动纤毛。 二者间的区别是如何形成的呢？ 研究者们分析这两类脊椎动物中不同的基因，鉴定出了五个编码胞外蛋白的基因，其中 CIROP 基因的功能此前未知。 研究表明， CIROP 在有鞭毛 LRO 中特异表达，在 …

Clinical resource with information about CIROP, Heterotaxy, visceral, 12, autosomal, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.