2023年6月30日 · For reasons arising from molecular orbital interactions, platin has a square planar geometry at the platinum atom. That arrangement results in two possible ways the ligands could be connected. The two sets of like ligands could be connected on the same side of the square or on opposite corners.

2006年3月1日 · Inside a cell, cisplatin loses its two chloride ions, creating a reactive species that forms bonds with DNA bases. Because of the cis geometry of these bonds, cisplatin easily forms crosslinks between bases, as shown in Figure 2.

2025年1月3日 · The structures of cis-platin and trans-platin. The cis-platin works by binding to the nitrogen atoms on the bases in DNA. The cis-platin passes through the cell membrane and undergoes ligand exchange where the chlorines are replaced by water molecules. The nitrogen is a better ligand than water and forms dative covalent bonds with the cis-platin

2017年4月5日 · The present theoretical investigation of the structure and vibrational spectra of cisplatin is based on the latest X-ray data reported by Weller et al. and aims to demonstrate the importance of the intermolecular interactions for reliable prediction of …

2015年11月5日 · Different DFT methods are assessed for predicting the structures of cisplatin and transplatin. The vibrational modes were investigated and assigned in detail for cisplatin and transplatin. The chemical reactivity of cisplatin and transplatin was …

Cisplatin is an alkylating-like inorganic platinum agent (cis-diamminedichloroplatinum) with antineoplastic activity. Cisplatin forms highly reactive, charged, platinum complexes which bind to nucleophilic groups such as GC-rich sites in DNA inducing intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links. These cross ...

The EICSs of monoaquated cisplatin yield maxima of 12.54 × 10⁻²⁰ m² at 82.8 eV for the DM method and of 9.74 × 10⁻²⁰ m² at 106 eV for the (R)BEB method(s), diaquated cisplatin yields ...

a) Using the simplified DNA below, show two possible ways that cisplatin can bind by ligand substitution to a guanine base. b) Transplatin is a geometric stereoisomer of cisplatin and does not work as an anticancer drug. Explain why. As the two Cl-ligands are opposite each other the cisplatin cannot use them both to substitute on

Molecular structure of cisplatin: This platinum compound is centered around two adjacent chloride ligands (on the left) and two amine groups (on the right). Source publication Cisplatin-Based...

2022年3月1日 · Herein, the mono-substituent effect of X@B 12 N 12 (X = F, Cl, and Br) on the geometric structure, electronic properties, and hydrolysis mechanism of cisplatin has been systemically examined by the density functional theory (DFT).