2024年12月24日 · CITED2 (Cbp/P300 Interacting Transactivator With Glu/Asp Rich Carboxy-Terminal Domain 2) is a Protein Coding gene. Diseases associated with CITED2 include Atrial Septal Defect 8 and Ventricular Septal Defect 2 .

"CITED2 is expressed in human adrenocortical cells and regulated by basic fibroblast growth factor".

2024年9月17日 · Stanford Elsevier Top Scientists List of the world’s best scientists for 2024 is out now! This list, made by Stanford University and Elsevier, shows the top 2% of scientists from all over the world. What’s This List All About? This list shows which scientists have had the biggest impact in their fields.

2012年7月20日 · Here, we show that Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 2 (CITED2), a novel MYC-interacting transcriptional modulator, responds to TGF- α induction and...

2002年7月29日 · Cited2 is a cAMP-responsive element-binding protein (CBP)/p300 interacting transcriptional modulator and a proposed negative regulator for hypoxia-inducible factor (HIF)-1α through its competitive binding with HIF-1α to CBP/p300.

Specificity of RNA expression in 17 cancer types is categorized as either cancer enriched, group enriched, cancer enhanced, low cancer specificity and not detected. The RNA data was used to cluster genes according to their expression across cell lines.

2016年12月1日 · These results suggest that CITED 2 plays important roles in the progression and chemoresistance of breast carcinoma and that CITED 2 status is a potent prognostic factor in breast cancer patients.

CITED2 (CBP/p300-interacting transactivator with Glu/Asp-rich C-terminal domain, 2) is a ubiquitously expressed protein exhibiting a high affinity for the CH1 domain of the transcriptional co-activators CBP/p300, for which it competes with hypoxia-inducible factors (HIFs).

CREB 2-binding protein (CBP)/p300 interacting transactivator with glutamic acid (Glu) and aspartic acid (Asp)-tail 2 (Cited2) is a multifunctional protein essential for mouse embryogenesis 1–4. Embryos with a deletion of Cited2 have defects in multiple organs including the heart, liver, and adrenal glands and do not survive beyond E14.5 1–4 .

2014年1月3日 · Compared with its parental wild type counterpart, Cited2 (Δ/-) ESCs have enhanced glycolysis, alternations in mitochondria morphology, reduced glucose oxidation, and decreased ATP content. Cited2 is recruited to the hexokinase 1 (HK1) gene promoter to regulate transcription of HK1, which coordinates glucose metabolism in wild type ESCs.