68379 Ensembl ENSG00000148337 ENSMUSG00000039205 UniProt Q9ULV3 n/a RefSeq (mRNA) NM_001131015 NM_001131016 NM_001131017 NM_001131018 NM_001257975 NM_001257976 NM_012127 NM_001252534 NM_001252536 NM_001252537 NM_001252538 NM_028412 RefSeq (protein) NP_001124487 NP_001124488 NP_001124489 NP_001124490 NP_001244904 NP_001244905 NP_036259 n/a Location (UCSC) Chr 9: 128.16 – 128.2 Mb …

2024年12月24日 · Complete information for CIZ1 gene (Protein Coding), CDKN1A Interacting Zinc Finger Protein 1, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium

2008年4月4日 · Ciz is a zinc finger transcription factor with nucleocytoplasmic shuttling activity. Ciz-deficient mice show high bone mass phenotype. As a first step to address how Ciz suppresses bone formation, we examined the binding partners of …

In this paper, we identified another novel ligand of the Cas SH3 domain and named it CIZ (for Cas-interacting zinc finger protein). CIZ is shown to bind Cas in cells, is located at focal adhesions and in the nucleus, and shuttles in and out of the nucleus.

2016年12月27日 · Precise duplication of the genome is a prerequisite for the health and longevity of multicellular organisms. The temporal regulation of origin specification, replication licensing, and firing at replication origins is mediated by the cyclin-dependent kinases. Here the role of Cip1 interacting Zinc f …

We showed that CIZ is a nucleocytoplasmic shuttling protein, by using the transient interspecies heterokaryon formation assay. In order to search for the targets of CIZ in nucleus, we determined the DNA binding consensus of CIZ as (G/C)AAAAA(A) by cyclic amplification and selection of targets analysis.

2000年12月15日 · Analysis of the promoter region of type I collagen gene identified the presence of a consensus CIZ-binding sequence, which indeed conferred responsiveness to CIZ overexpression to a heterologous promoter. These data indicate that CIZ acts as a novel regulatory molecule in controlling osteoblastic function.

Lead researcher: Professor Dawn Coverley, Department of Biology Disruption of epigenetic control of gene expression contributes to both the initiation and progression of human tumours. We use the inactive X chromosome (Xi), whose genes are normally repressed by stable modification of histone proteins, as a model to understand how epigenetic landscape is maintained through cell division.

2006年4月15日 · Overexpression of cas-interacting zinc finger protein (CIZ) suppresses proliferation and enhances expression of type I collagen gene in osteoblast-like MC3T3E1 cells

2000年3月1日 · CIZ consists of the following: a putative leucine zipper; a serine/threonine-rich region; a proline-rich sequence; five, six, or eight Krüppel-type C2H2 zinc fingers; and the glutamine-alanine ...