Claudin 4, also known as CLDN4, is a protein which in humans is encoded by the CLDN4 gene. It belongs to the group of claudins . This gene encodes an integral membrane protein , which belongs to the claudin family.

2022年9月26日 · 进一步的实验数据表明，稳定敲低CLDN4，可抑制异种移植小鼠胶质瘤的生长和侵袭，且联合ITD-1治疗，对小鼠肿瘤的抑制效果更好 [1] 。CLDN4作为Claudins家族的重要分子，在各种类型肿瘤中广泛出现高表达或表达缺失。陆续有研究表明，CLDN4可作为治疗肿瘤的特定 …

2024年12月24日 · CLDN4 (Claudin 4) is a Protein Coding gene. Diseases associated with CLDN4 include Ovarian Cystadenoma and Williams-Beuren Syndrome. Among its related pathways are Blood-Brain Barrier and Immune Cell Transmigration: VCAM …

The cell cluster C1, classified as Epithelial Cell Adhesion Molecule (EpCAM)+ metastatic cancer cell and correlated with activation of tight junction and adherence junction, was significantly enriched in the recurrent MPE group, in which Claudin-4 (CLDN4) was identified.

Claudins 是完整的膜蛋白，是上皮细胞紧密连接的组成部分，可调节溶质和离子通过细胞旁空间的运动。 这种蛋白质是产气荚膜梭状芽孢杆菌肠毒素 (CPE) 的高亲和力受体，可能在出生前后的内脏器官发育和功能中发挥作用。 该基因在 Williams-Beuren 综合征中被删除，这是一种影响多个系统的神经发育障碍。 [RefSeq 提供，2013 年 9 月] The protein encoded by this intronless gene belongs to the claudin family.

2023年3月13日 · Claudin-4 (CLDN4) is a key component of tight junctions (TJs) in epithelial cells. CLDN4 is overexpressed in many epithelial malignancies and correlates with cancer progression. Changes in CLDN4 expression have been associated with epigenetic factors (such as hypomethylation of promoter DNA), inflam …

CLDN4, clustered with CLDN3 at human chromosome 7q11, is a four-transmembrane protein with WWCC motif, defined by W-X(17-22)-W-X(2)-C-X(8-10)-C.

2023年3月13日 · CLDN4 is the major CLDN involved in TJs in epithelial cells, such as those in the intestines and lungs, and is associated with many epithelial malignancies [4, 5]. This review provides an overview of CLDN4 expression, function, and the therapeutic targeting of this protein.

2022年4月13日 · Our results revealed that CLDN4 was significantly upregulated in glioma specimens and cells. The inhibition of CLND4 expression could inhibit mesenchymal transformation, cell invasion, cell...

CLDN4：作为潜力肿瘤治疗靶标，展示联合用药潜力. Claudin 4( CLDN4 )是一种紧密连接蛋白，是Claudin 家族的一员，Claudin 蛋白均由4个跨膜结构域构成，N端和C端均位于细胞内部，细胞膜外有2个长度不等的环，可以和临近其他同类型的环相接触构成细胞间的紧密连接．