2017年8月21日 · Here we show that CLEC5A is involved in neutrophil extracellular trap formation and the production of reactive oxygen species and proinflammatory cytokines in response to Listeria monocytogenes.

2024年12月24日 · CLEC5A (C-Type Lectin Domain Containing 5A) is a Protein Coding gene. Diseases associated with CLEC5A include Dengue Virus and Penis Squamous Cell Carcinoma. Among its related pathways are Innate Immune System and DAP12 interactions. Gene Ontology (GO) annotations related to this gene include carbohydrate binding and virus receptor activity.

CLEC5A is a spleen tyrosine kinase (Syk)-coupled C-type lectin that is highly expressed by monocytes, macrophages, neutrophils, and dendritic cells and interacts with virions directly, via terminal fucose and mannose moieties of viral glycans.

2017年8月21日 · The C-type lectin member 5A (CLEC5A) is a pattern recognition receptor for members of the Flavivirus family and has critical functions in response to dengue virus and Japanese encephalitis virus.

2019年10月8日 · Here, we report a protein-coding gene CLEC5A, which is the top 1 gene by univariate Cox regression analysis of 524 primary GBM samples. Expression of CLEC5A is significantly correlated with...

2022年8月1日 · CLEC5A is a potential prognostic biomarker of diverse cancers and a target for anti-tumor therapy. CLEC5A overexpresses in multiple cancers in contrast to normal tissues, and high CLEC5A expression predicts poor prognosis of patients and immune infiltration.

2018年1月1日 · CLEC5A is a C-type lectin that activates macrophages and osteoclasts by signaling through DAP-12 and DAP-10. CLEC5A binds to Dengue and Japanese encephalitis virus, but specific viral ligands remain unknown. There are no known endogenous ligands.

2017年1月1日 · We identified that CLEC5A, a C-type lectin receptor which has previously been reported to mediate flavivirus-induced inflammatory responses, enhanced induction of proinflammatory cytokines and chemokines in myeloid cells after influenza infections.

2022年7月31日 · We found that gene mutations and methylation levels of CLEC5A can lead to abnormally high CLEC5A expression, which is significantly associated with increased immune infiltration of macrophages, CAF, and Treg and poor prognosis of various cancers.

The human C-type lectin-like molecule CLEC5A is a critical macrophage receptor for dengue virus. The binding of dengue virus to CLEC5A triggers signaling through the associated adapter molecule DAP12, stimulating proinflammatory cytokine release.