The C-type lectin receptor CLEC9A mediates antigen uptake …
2012年3月8日 · CLEC9A is a recently discovered C-type lectin receptor involved in sensing necrotic cells. In humans, this receptor is selectively expressed by BDCA3 + myeloid dendritic …
CLEC9A Is a Novel Activation C-type Lectin-like ... - ScienceDirect
2008年6月13日 · Furthermore, Dectin-1 and CLEC-2 have been shown to be capable of directly triggering cellular activation through cytoplasmic immunoreceptor tyrosine-based activation …
Exploring Clec9a in dendritic cell-based tumor immunotherapy for ...
2025年2月7日 · Through activation of the immunoreceptor tyrosine-based activation motif (ITAM)-spleen tyrosine kinase (Syk) signaling pathway, Clec9a promotes downstream immune …
HemITAM: A single tyrosine motif that packs a punch
2017年12月5日 · DNGR-1 (encoded by CLEC9A) is a type II transmembrane CTLR that exists as a disulfide-linked homodimer primarily on human BDCA3 + DCs and mouse CD8α + DCs but …
C-Type Lectin-Like Receptors: Head or Tail in Cell Death Immunity
2020年2月17日 · CLEC9A, via Hemi-ITAM (HITAM) plays a key role in CD8 + T cell cross-priming. In addition, CLEC9A can activate SHP-1 to exert inhibitory feedback and restrain …
C-type lectin receptor-induced NF-κB activation in innate ... - Nature
2012年1月16日 · The cytoplasmic tail of Dectin-1, CLEC-2, CLEC9A and LOX1 contains immunoreceptor tyrosine-based activation motif (ITAMs) , and ligation of these receptors …
DNGR-1, an F-Actin-Binding C-Type Lectin Receptor Involved
2016年3月17日 · DNGR-1 (also known as CLEC9A) is a C-type lectin homodimeric innate immune receptor that detects the presence of dead cells (Sancho et al. 2009). In both mouse …
树突状细胞表面受体C型凝集素结构域家族9成员A的研究进展 - 百 …
c型凝集素结构域家族9成员a(clec9a)也称dc-nk凝集素家族受体(dngr-1),其在人树突状细胞(dc)亚群表面表达,是一种特异性的标志物.它能通过识别受损细胞暴露的微丝及微丝上的丝状肌动蛋白 …
The dendritic cell receptor Clec9A: receptor regulation and …
2022年10月1日 · Clec9A is a DC-specific Damage-Associated Molecular Pattern receptor, that is expressed by mouse and human cross-presenting DC subsets. Clec9A recognises actin …
Exploring Clec9a in dendritic cell-based tumor immunotherapy for ...
Clec9a + cDC1s can be generated in both murine and human models, providing a platform to study its role as an endocytic receptor. Through activation of the immunoreceptor tyrosine …