2024年12月24日 · This gene encodes a member of the chloride intracellular channel (CLIC) family of chloride ion channels. The encoded protein associates with actin-based cytoskeletal structures and may play a role in multiple processes including hair cell stereocilia formation, myoblast proliferation and glomerular podocyte and endothelial cell maintenance.

2023年10月17日 · In vertebrates, the CLIC5 gene encodes two different isoforms, CLIC5A and CLIC5B. In addition to its ion channel activity, there is evidence for further functions of CLIC5A, such as the...

Chloride intracellular channel protein 5 is a protein that in humans is encoded by the CLIC5 gene. [5][6] CLIC5 exists in two alternative splice variants, a smaller CLIC5A and larger CLIC5B protein. CLIC5A is expressed chiefly in the renal glomerulus, specifically in podocytes.

CLIC5 is co-localized and associated with ERM proteins and Podocalyxin in the glomerular podocytes, and thereby plays an important role in the development or maintenance of a...

This gene encodes a member of the chloride intracellular channel (CLIC) family of chloride ion channels. The encoded protein associates with actin-based cytoskeletal structures and may play a role in multiple processes including hair cell stereocilia formation, myoblast proliferation and glomerular podocyte and endothelial cell maintenance.

ID: CLIC5_HUMAN DESCRIPTION: RecName: Full=Chloride intracellular channel protein 5; FUNCTION: Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. May play a role in the regulation of transepithelial ion …

This gene encodes a member of the chloride intracellular channel (CLIC) family of chloride ion channels. The encoded protein associates with actin-based cytoskeletal structures and may play a role in multiple processes including hair cell stereocilia formation, myoblast proliferation and glomerular podocyte and endothelial cell maintenance.

2024年2月8日 · Here, we unveil the novel functionality of CLIC5 as a fusogenic protein. Building upon the emerging evidence of CLICs' involvement in membrane remodeling events, we demonstrate that purified CLIC5 directly interacts with artificial membranes.

2025年2月8日 · This gene encodes a member of the chloride intracellular channel (CLIC) family of chloride ion channels. The encoded protein associates with actin-based cytoskeletal structures and may play a role in multiple processes including hair cell stereocilia formation, myoblast proliferation and glomerular podocyte and endothelial cell maintenance.

clic5是一种单次跨膜蛋白，属于氯离子通道clic家族，含有一个gstc末端结构域。 CLIC5能够插入膜中并形成由肌动蛋白调节的选择性离子通道，可能负责运输氯离子，参与调节跨上皮离子吸收和分泌。