
CLIC4 localizes to mitochondrial-associated membranes and
2022年10月21日 · Here, we found chloride intracellular channel protein (CLIC4) presence in MAMs of cardiomyocytes and demonstrate its role in modulating ER and mitochondrial calcium homeostasis under physiological and pathological conditions. In a murine model, loss of CLIC4 increased myocardial infarction and substantially reduced cardiac function after IR injury.
CLIC4 localizes to mitochondrial-associated membranes and
2022年10月22日 · Here, we found chloride intracellular channel protein (CLIC4) presence in MAMs of cardiomyocytes and demonstrate its role in modulating ER and mitochondrial calcium homeostasis under physiological and pathological conditions. In a murine model, loss of CLIC4 increased myocardial infarction and substantially reduced cardiac function after IR injury.
Data supporting characterization of CLIC1, CLIC4, CLIC5 and …
We demonstrate that the predominant CLICs in the heart, namely CLIC1, CLIC4 and CLIC5, show differential distribution in endoplasmic reticulum. CLIC1 and CLIC4 both show co-localization to the endoplasmic reticulum whereas CLIC5 does not.
CLIC4/Arf6 Pathway - PubMed
2019年1月4日 · Methods and results: Proteomic analysis of CLIC4-interacting proteins in human pulmonary artery endothelial cells identified regulators of endosomal trafficking, including Arf6 (ADP ribosylation factor 6) GTPase activating proteins and clathrin, while CLIC4 overexpression affected protein regulators of vesicular trafficking, lysosomal function ...
CLIC4/Arf6 Pathway | Circulation Research - AHA/ASA Journals
2018年10月15日 · Increased expression of CLIC4 (chloride intracellular channel 4) is a feature of endothelial dysfunction in pulmonary arterial hypertension, but its role in disease pathology is not fully understood. To identify CLIC4 effectors and evaluate strategies targeting CLIC4 signaling in pulmonary hypertension.
CLIC4/Arf6 Pathway: A New Lead in BMPRII Inhibition in …
Increased expression of CLIC4 (chloride intracellular channel 4) is a feature of endothelial dysfunction in pulmonary arterial hypertension, but its role in disease pathology is not fully understood. To identify CLIC4 effectors and evaluate strategies targeting CLIC4 signaling in pulmonary hypertension.
CLIC4 Regulates Endothelial Barrier Control by Mediating PAR1 …
2023年6月15日 · Using a newly generated Clic4 floxed mouse strain, we discovered that murine Clic4 is required in the endothelium for PAR1-mediated microvascular permeability in the lung. These findings establish that CLICs function as essential effectors in several endothelial GPCR pathways that regulate small GTPases and endothelial barrier integrity.
CLIC4 - Wikipedia
Chloride intracellular channel 4 (CLIC4) protein, encoded by the clic4 gene, is a member of the p64 family; the gene is expressed in many tissues. These channels are implicated in angiogenesis, pulmonary hypertension, cancer, and cardioprotection from …
CLIC4 and CLIC5, Mitochondrial Chloride Channel Proteins …
2018年2月2日 · Amongst the six mammalian paralogs (CLIC1-CLIC6), CLIC4 and CLIC5 are present in the cardiac mitochondria of rats. CLIC4, an outer mitochondrial membrane protein modulated the calcium retention capacity (CRC) of the mitochondria whereas CLIC5, present in the inner mitochondrial membrane maintains the reactive oxygen species (ROS) generation.
Molecular identity of cardiac mitochondrial chloride intracellular ...
In this study, we report the presence of unique dimorphic chloride intracellular channel (CLIC) proteins namely CLIC1, CLIC4 and CLIC5 as abundant CLICs in the rodent heart. Further, CLIC4, CLIC5, and an ortholog present in Drosophila (DmCLIC) localize to adult cardiac mitochondria.
CLIC4 Gene - GeneCards | CLIC4 Protein | CLIC4 Antibody
2024年12月24日 · Chloride intracellular channel 4 (CLIC4) protein, encoded by the CLIC4 gene, is a member of the p64 family; the gene is expressed in many tissues and exhibits a intracellular vesicular pattern in Panc-1 cells (pancreatic cancer cells).
Chloride Channels are Involved in the Development of Atrial ...
2017年8月31日 · In this study, human atrial tissues from the patients with rheumatic mitral valve disease in either sinus rhythm or persistent AF were analyzed using a combined transcriptomic and proteomic...
CLIC4/Arf6 Pathway - PMC - National Center for Biotechnology …
2019年1月1日 · Increased expression of CLIC4 (chloride intracellular channel 4) is a feature of endothelial dysfunction in pulmonary arterial hypertension, but its role in disease pathology is not fully understood. To identify CLIC4 effectors and evaluate strategies targeting CLIC4 signaling in pulmonary hypertension.
Here, we found chloride intracellular channel protein (CLIC4) presence in MAMs of cardiomyocytes and demonstrate its role in modulating ER and mitochondrial calcium homeostasis under physiological and pathological conditions. In a murine model, loss of CLIC4 increased myocardial infarction and substantially reduced cardiac function after IR injury.
Data supporting characterization of CLIC1, CLIC4, CLIC5 and ... - PubMed
2016年3月26日 · We demonstrate that the predominant CLICs in the heart, namely CLIC1, CLIC4 and CLIC5, show differential distribution in endoplasmic reticulum. CLIC1 and CLIC4 both show co-localization to the endoplasmic reticulum whereas CLIC5 does not.
CLIC4 localizes to mitochondrial-associated membranes and …
Here, we found chloride intracellular channel protein (CLIC4) presence in MAMs of cardiomyocytes and demonstrate its role in modulating ER and mitochondrial calcium homeostasis under physiological and pathological conditions. In a murine model, loss of CLIC4 increased myocardial infarction and substantially reduced cardiac function after IR injury.
Molecular identity of cardiac mitochondrial chloride intracellular ...
2016年3月1日 · In this study, we report the presence of unique dimorphic chloride intracellular channel (CLIC) proteins namely CLIC1, CLIC4 and CLIC5 as abundant CLICs in the rodent heart. Further, CLIC4, CLIC5, and an ortholog present in Drosophila (Dm CLIC) localize to …
Gene Hackman died of heart disease and his wife died of …
2025年3月7日 · Actor Gene Hackman died of natural causes, New Mexico’s chief medical examiner said today. His wife, Betsy Arakawa, died of hantavirus pulmonary syndrome and likely passed before her husband ...
(PDF) CLIC4 localizes to mitochondrial-associated membranes and ...
2022年10月21日 · Here, we found chloride intracellular channel protein (CLIC4) presence in MAMs of cardiomyocytes and demonstrate its role in modulating ER and mitochondrial calcium homeostasis under...
Data supporting characterization of CLIC1, CLIC4, CLIC5 and …
2016年6月1日 · We demonstrate that the predominant CLICs in the heart, namely CLIC1, CLIC4 and CLIC5, show differential distribution in endoplasmic reticulum. CLIC1 and CLIC4 both show co-localization to the endoplasmic reticulum whereas CLIC5 does not.