Biological properties of bone marrow plasma cells influence their ...
First, the presence of at least 10% clonal BMPC is mandatory for separation of plasma cell myeloma from monoclonal gammopathy of undetermined significance (MGUS), and second, …
MGUS - To Marrow or not to Marrow? • The Blood Project
Clonal plasma cell percentage on bone marrow exam, preferably from a core biopsy specimen, of ≥ 60%. Serum involved to uninvolved free light chain (FLC) ratio of ≥ 100 if the absolute level …
Extramedullary disease in multiple myeloma - PMC
Multiple Myeloma (MM) is defined by the presence of ≥10% clonal bone marrow (BM) plasma cells (PC) associated with features of hypercalcemia, renal failure, anemia or lytic bone lesions …
Recruitment of plasma cells from IL-21-dependent and IL-21
2024年5月17日 · Here we define human BMPC heterogeneity and track the recruitment of antibody-secreting cells (ASC) from SARS-CoV-2 vaccine immune reactions to the bone …
Clonal plasma cells from monoclonal gammopathy of …
2005年1月27日 · Accordingly, clonal BMPC in MGUS displayed a significant increase in HLA-I antigen-presenting molecules, which progressively decreased in aggressive forms of MG, MM …
Temporal dynamics and genomic programming of plasma cell fates
2024年5月2日 · Clonal tracing using single-cell RNA sequencing and B cell antigen receptor sequencing in spleen and bone marrow compartments, coupled with adoptive transfer …
Clonal plasma cells from monoclonal gammopathy of undetermined ... - PubMed
The immunological bone marrow (BM) microenvironment plays a major role in controlling growth and survival of clonal plasma cells (PC); this might translate into different patterns of …
Smoldering multiple myeloma: prevalence and current evidence …
MGUS is defined by a serum M-protein level of <3 g/dL, a bone marrow plasma cell (BMPC) infiltration of <10%, and the absence of clinical complications. SMM is defined by serum M …
(PDF) Clonal plasma cells from monoclonal gammopathy of …
2005年4月1日 · Clonal plasma cells from monoclonal gammopathy of undetermined significance, multiple myeloma and plasma cell leukemia show different expression profiles of molecules …
Bone marrow aspirate or biopsy for multiple myeloma: when …
2024年7月27日 · A diagnosis of MM requires ≥10% clonal bone marrow plasma cells (BMPC) or a biopsy-proven plasmacytoma. This is usually associated with a monoclonal immunoglobulin …