ClpXP is a AAA+ protease that uses the energy of ATP binding and hydrolysis to perform mechanical work during targeted protein degradation within cells. ClpXP consists of hexamers …

2012年1月1日 · ClpXP is a AAA+ protease that uses the energy of ATP binding and hydrolysis to perform mechanical work during targeted protein degradation within cells. ClpXP consists of …

ClpXP is an archetypical and well-studied AAA+ protease present in most eubacteria and the mitochondria of eukaryotic cells (Baker and Sauer, 2012; Olivares et al., 2018). It consists of …

2019年10月3日 · The ClpXP machinery is a two-component protease complex that performs targeted protein degradation in bacteria and mitochondria. The complex consists of the AAA+ …

2020年10月9日 · Mitochondrial ClpP is a stable heptamer ring with peptidase activity that forms a multimeric complex with the ATP-dependent unfoldase ClpX (ClpXP) leading to proteolytic …

2021年12月21日 · ClpXP is an archetypical AAA+ protease, consisting of ClpX and ClpP. ClpX is an ATP-dependent protein unfoldase and polypeptide translocase, whereas ClpP is a self …

2011年4月29日 · We report direct observations of mechanical, force-induced protein unfolding by the ClpX unfoldase from E. coli, alone, and in complex with the ClpP peptidase. ClpX …

ClpXP is a AAA+ protease that uses the energy of ATP binding and hydrolysis to perform mechanical work during targeted protein degradation within cells. ClpXP consists of hexamers …

马萨诸塞大学Peter Chien实验室发表在Biochemistry上的一篇“The Cleavage Profile of Protein Substrates by ClpXP Reveals Deliberate Starts and Pauses” 使用一系列结构上不同的底物和 …

2003年3月1日 · Here, we report the identification of more than 50 E. coli proteins that are trapped in a ClpX-dependent fashion within an active-site mutant of ClpP. Analysis of these ClpXP …