Ciliary neurotrophic factor (CNTF) is a member of interleukin-6 type cytokine family. The CNTF receptor complex is a heterodimer including gp130 and CNTF receptor α (CNTFRɑ) proteins triggering the activation of multiple intracellular signaling ...

Ciliary neurotrophic factor is a protein that in humans is encoded by the CNTF gene. [5] [6] [7] The protein encoded by this gene is a polypeptide hormone and neurotrophic factor whose actions have mainly been studied in the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neural populations including ...

2025年1月15日 · 本研究表明，CNTF联合RA可以诱导成肌细胞实现类神经分化，这为研究神经肌肉系统的交互作用提供了新的思路和方法。 同时，研究发现REST在成肌细胞类神经分化过程中发挥重要作用，这为进一步研究REST的功能和作用机制提供了重要的线索。 然而，本研究仍存在一些局限性。 首先，本研究仅在体外环境下进行实验，未能完全模拟人体内的复杂环境。 其次，关于REST的具体作用机制仍需进一步研究。 因此，未来研究可以进一步探讨CNTF、RA …

Single particle electron microscopic analysis of the full-length gp130/LIF-R/CNTF-Ra/ CNTF quaternary complex elucidates an asymmetric structural arrangement, in which the receptor extra-cellular and transmembrane segments join as a con-tinuous, rigid unit, poised to sensitively transduce ligand engagement to the membrane-proximal intra-cellular...

2015年10月1日 · CNTF-producing cells are being currently evaluated for treatment of retinal degeneration for fast-track approval by the FDA. Ciliary neurotrophic factor (CNTF) is the most extensively studied member of the cytokine family that signal through intracellular chains of the gp130/LIFRβ receptor.

2022年11月17日 · Rhee et al. demonstrates that the potent neuroprotective agent CNTF significantly impacts metabolism of degenerating retinas, thus revealing cellular mechanisms underlying enhanced neuronal ...

Ciliary neurotrophic factor (CNTF) is a neurocytokine, which could promote survival and/or differentiation in many cell types. In this study, the biological effects of CNTF on retinoic acid (RA)-predifferentiated SH-SY5Y neuroblastoma cells and the underlying molecular mechanism of this effect were …

CNTF是神经元和少突胶质细胞的有效生存因子，它可能与减少炎症性发作期间组织破坏有关。 中枢神经系统外，CNTF的主要靶组织之一是骨骼肌。 目前已经证明CNTF还可以在骨表面细胞中表达，并能降低成骨细胞活性。 CNTF是一种多能性神经细胞因子，是一种潜在的抗肥胖治疗方法。 CNTF在中枢和外周发挥作用，在克服“瘦素抵抗”的同时模仿瘦素的生物学作用，即使在终止治疗后，如果集中给药，它仍然有效，并且似乎可以减少与肝脏和骨骼肌中脂质积聚相关的炎症信号 …

方法 以cntf 诱导c2c12 去分化，再以ra 诱导 c2c12 类神经分化。 通过细胞形态学、细胞免疫荧光、流式细胞术、Western blot 等技术对去分化及类神经 分化的细胞进行鉴定及相关分析，比较细胞类神经分化前后REST 表达变化。

2025年1月10日 · 1.cntf联合ra诱导成肌细胞类神经分化. 实验结果显示，在cntf和ra的联合作用下，成肌细胞的形态逐渐发生变化，呈现出神经细胞的特征。同时，实时荧光定量pcr结果显示，与神经分化相关的基因表达水平显著提高。