脉络膜新生血管 (choroidal neovascularition，CNV)又名视网膜下新生血管，是来自正常脉络膜组织的增殖血管，可通过 Bruch膜 破损处进入Bruch膜与 视网膜色素上皮层 (retinal pigment epithelium，RPE)之间、视网膜神经上皮层与RPE之间、RPE与脉络膜之间。 CNV是许多脉络膜视网膜疾病，如年龄相关性黄斑变性渗出期、高度近视黄斑变性等发生发展中的重要病理机制。 为了进一步发现这些疾病确切的发病机理，制作接近临床特征的CNV动物模型是必要的前提。 目 …

Animal models of choroidal neovascularization (CNV) are extensively used to characterize the pathophysiology of chorioretinal diseases with CNV formation and to evaluate novel treatment strategies. This systematic review aims to give a detailed overview of …

2013年10月17日 · This protocol includes details of how to induce CNV, including laser induction, lesion excision, processing and different approaches to quantify neoformed vasculature.

Purpose: Animal models of choroidal neovascularization (CNV) are extensively used to characterize the pathophysiology of chorioretinal diseases with CNV formation and to evaluate novel treatment strategies. This systematic review aims to give a detailed overview of contemporary animal models of CNV.

The mouse laser-induced choroidal neovascularization (CNV) model has been a crucial mainstay model for neovascular age-related macular degeneration (AMD) research. By administering targeted laser injury to the RPE and Bruch’s membrane, the procedure induces angiogenesis, modeling the hallmark pathology observed in neovascular AMD.

In this study, SD-OCT allowed a spatial and temporal in vivo analysis of the laser-induced CNV model in mice. CNV formation was monitored from its early induction, through the development of a leaking neovascular lesion, and its subsequent regression.

The laser-induced choroidal neovascularization (CNV) model is an established method used to evaluate therapies for wet age-related macular degeneration (wet AMD), a leading cause of blindness in our senior population. Study design is flexible, factoring in the nature of the compound and its intended clinical regimen.

2023年9月1日 · Animal models of choroidal neovascularization (CNV) are extensively used in translational studies of CNV formation and to evaluate angiostatic treatment strategies. However, the current paucity of large animal models compared with rodent models constitutes a knowledge gap regarding the clinical translation of findings.

2020年6月12日 · Summary: The choroidal neovascularization model is one of the most popular preclinical models to study pathologic neovascularization in vivo. In 1989, Dobi and colleagues were first to describe a rat choroidal neovascularization model …

The mouse model of laser-induced choroidal neovascularization (CNV) has been used extensively in studies of the exudative form of age-related macular degeneration (AMD). This experimental in vivo model relies on laser injury to perforate Bruch's membrane, resulting in subretinal blood vessel recruit …