Inducible T-cell costimulator (also called CD278) is an immune checkpoint protein that in humans is encoded by the ICOS (I nducible T-cell COS timulator) gene. [5][6][7] [8][9] The protein …

可诱导共刺激受体（Inducible T cell CO-Stimulator，ICOS）又称CD278，最早于1999年被科学家发现[1]，与CTLA-4、PD-1等同属于免疫球蛋白超家族成员，主要表达于活化的T细胞上，可 …

2020年10月8日 · Here, we report the crystal structure of the co-complex between human ICOS and its ligand ICOS-L at 3.3 Å resolution, which reveals the molecular details of immune …

2002年7月30日 · ICOS提供的共刺激信号能促进T细胞增殖，调节T细胞的分化，维持活化后T细胞（包括记忆性T细胞）的效应和功能，参与T/B协同，影响Ig类型转换。 目前认为CD28在免疫 …

1999年1月21日 · Matching CD28 in potency, ICOS enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, upregulation of molecules that …

1999年12月16日 · Matching CD28 in potency, ICOS enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, upregulation of molecules that …

Introduction: The promotion of antitumor response by targeting co-stimulatory B7 superfamily members has become evident to create a new wave of cancer immunotherapy. Inducible Co …

2018年3月13日 · One promising new avenue of investigation is ICOS, an immune checkpoint expressed on activated T cells, which has opposing functions in sustaining T cell activation …

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ICos-mediated signaling mainly generates Th1 (T-Helper-1) and Th2 responses. Even though ICos belongs to the CD28 family of receptors and CD28 is a major positive co-stimulatory …