Development of the cochlea | Development - The Company of …
2020年6月22日 · In this Review, we focus on recent discoveries examining different aspects of cochlear development, including patterning and outgrowth of the cochlear duct, cellular differentiation within the sensory epithelium, and HC formation and polarization.
Hearing - Inner Ear Development - Embryology
4 天之前 · To examine cochlear development more closely, we transcriptionally profile approximately 30,000 isolated mouse cochlear cells collected at four developmental time points. Here we report on the analysis of those cells including the identification of both known and unknown cell types.
Where hearing starts: the development of the mammalian cochlea
In this review, we briefly discuss the evolutionary origins of the mammalian cochlea, and then describe the successive developmental processes that lead to its induction, cell cycle exit, cellular patterning and the establishment of topologically distinct frequency responses along its length.
Anatomy and Embryology of the Middle Ear, Labyrinth, and …
2024年10月1日 · The intricate anatomy and embryology of the middle ear, labyrinth, and vertigo-related intracranial pathways involve complex developmental processes and contributions from multiple germ layers. The middle ear, comprised of the tympanic cavity, ossicles, and Eustachian tube, develops from the first and second branchial arches and clefts.
Neurosensory development and cell fate determination in the …
In this study, we investigated the onset of hair cell differentiation and innervation in the human fetal cochlea at various stages of development. At 10 weeks of gestation, we observed a prosensory domain expressing SOX2 and SOX9/SOX10 within the cochlear duct epithelium.
Embryology of Inner Ear and Its Malformation | SpringerLink
2016年12月6日 · Embryologically the cochlea and their sensory cells develop and are completed at a relatively late stage of fetus compared with the vestibular organ (Fig. 2.1) [4]. The otocyst separates from the neural crest around gestation week 4, and the endolymphatic duct develops around gestation week 5.
Referateband: Embryology, Malformations, and Rare Diseases of …
2021年4月30日 · The cochlear nerve develops from a group of cells (neuroblasts) that derive from the medial part of the ear epithelium and pass into the underlying mesenchyme. They form the VIII th (vestibulocochlear) ganglion leading to the development of the 8 th cranial nerve 10.
Embryology of Ear (General) - SpringerLink
During the seventh week, cochlear duct epithelial cells differentiate to form the Organ of Corti. Initially, these epithelial cells are similar, but with further development, they form two ridges: an inner (the future spiral limbus) and outer ridge .
Growth and cellular patterning during fetal human inner ear …
2019年5月20日 · Progressive transformation of the otic placode into the functional inner ear during gestational development in humans leads to the acquisition of hearing perception via the cochlea and balance and spatial orientation via the vestibular organ.
Early fetal development of the human cochlea - PubMed
We evaluated histological sections taken from 20 fetuses: eight each at 8--9 weeks [early stage; 28--45 mm crown-rump length (CRL)] and 11--12 weeks (middle stage; 52--74 mm CRL), and four at 14--15 weeks (late stage; 90--110 mm CRL) of gestation.