2014年1月1日 · While coilin KD enhanced TRV, TBRV, TGMV, and BSMV pathogenicity, it had the completely opposite effect on PVY and TVCV, causing attenuation of infection (or …

We have shown by Western blot utilizing siRNA KD and coilin KO cell lines, Ni-NTA pulldown assays, and in vitro SUMOylation experiments that coilin plays a role in protein SUMOylation. …

Coilin-silenced (knocked down, KD) transgenic plants were generated by transgenic expression of two independent hairpin RNA constructs, which were designed to avoid “off-target” silencing.

2011年10月3日 · Coilin is considered to be the CB marker protein and is essential for proper CB formation and composition in mammalian cells. In order to characterize the role of coilin …

In this brief review, I focus on coilin and Cajal bodies. Coilin is a key scaffolding protein of Cajal bodies that is evolutionarily conserved in metazoans. Cajal bodies are thought to be one of the …

2015年6月12日 · Coilin is able to interact with mdm2/hdm2 ubiquitin ligase that ubiquitinates coilin resulting in its proteasomal degradation as demonstrated by its sensitivity to inhibitors, such as …

2014年11月6日 · Robust detection of snRNA transcripts correlated with coilin ChIP-seq peaks on snRNA genes, indicating that coilin binding to nascent snRNAs is a site-specific CB nucleator. …

We show that the CB protein coilin interacts with poly (ADP-ribose) polymerase 1 (PARP1), redistributes it to the nucleolus and modifies its function, and that these events are …

2022年7月7日 · Here we report that coilin is a regulator of miR-517-3p, sFlt-1, TNIP1, TNFSF15 and NF-κB activation, and this regulation is influenced by hypoxia. We also report that coilin …

Coilin-silenced (knocked down, KD) transgenic plants were generated by transgenic expression of two independent hairpin RNA constructs, which were designed to avoid “off-target” silencing.