2024年12月24日 · COL10A1 (Collagen Type X Alpha 1 Chain) is a Protein Coding gene. Diseases associated with COL10A1 include Metaphyseal Chondrodysplasia, Schmid Type and Craniometadiaphyseal Dysplasia, Wormian Bone Type .

Collagen alpha-1(X) chain is a protein that in humans is a member of the collagen family encoded by the COL10A1 gene. [5] [6] This gene encodes the alpha chain of type X collagen, a short chain collagen expressed by hypertrophic chondrocytes during endochondral ossification. Unlike type VIII collagen, the other short chain collagen, type X ...

COL10A1 promotes tumorigenesis by modulating CD276 in pancreatic adenocarcinoma. COL10A1 is a potential immunotherapy biomarker associated with immune infiltration and deficient mismatch repair in colon cancer.

该基因编码 X 型胶原蛋白的 α 链，这是一种短链胶原蛋白，在软骨内骨化过程中由肥大软骨细胞表达。 与 VIII 型胶原蛋白 (另一种短链胶原蛋白) 不同，X 型胶原蛋白是同源三聚体。 该基因的突变与 Schmid 型干骺端软骨发育不良 (SMCD) 和日本型脊椎干骺端发育不良 (SMD) 相关。 [RefSeq 提供，2008 年 7 月] This gene encodes the alpha chain of type X collagen, a short chain collagen expressed by hypertrophic chondrocytes during endochondral ossification.

2024年12月10日 · Title: Experimental validation and pan-cancer analysis identified COL10A1 as a novel oncogene and potential therapeutic target in prostate cancer. COL10A1 promotes tumorigenesis by modulating CD276 in pancreatic adenocarcinoma.

电泳迁移率变动测定和染色质免疫沉淀测定证实了 Cox-2 和 Col10a1 顺式增强子之间的相互作用，支持其作为候选 Col10a1 调节剂的作用。 总之，我们的数据支持软骨细胞肥大分化过程中包含 Cox-2、以 Runx2 为中心的 Col10a1 调节机制。

The study indicates that COL10A1 might participate in M2 macrophage polarization in prostate cancer. COL10A1 might be an innovative biomarker to evaluate tumor microenvironment immune cell infiltration and prognosis in prostate cancer.

2024年10月11日 · Collagen type X α1 chain (COL10A1), a gene encoding the α‑1 chain of type X collagen, serves a key role in conferring tensile strength and structural integrity to tissues. Upregulation of COL10A1 expression has been observed in different malignancies, including lung, gastric and pancreatic cancer, and is associated with poor prognosis.

Collagen type X alpha 1 (COL10A1) is a member of the collagen family and the main matrix component. However, COL10A1 expression and prognosis relationship remains unclear in gastric cancer (GC). Through the analysis of database of Oncomine, the Cancer Genome Atlas (TCGA) as well as the Gene Expressi …

2024年2月5日 · Analysis of Collagen type X alpha 1 (COL10A1) expression and prognostic significance in gastric cancer based on bioinformatics. Chen S, Wei Y, Liu H, Gong Y, Zhou Y, Yang H, Tang LChen S, et al. Bioengineered, 2021 Dec. PMID 33371777; Genome-Scale Analysis Identifies Novel Transcript-Variants in Esophageal Adenocarcinoma.