2014年9月15日 · In most Gram-negative bacteria, including Escherichia coli, ferric uptake regulator (Fur) regulates iron metabolism to precisely control cytoplasmic iron levels.

We investigated how E. coli Fur and its direct regulon (81 genes) have been evolved and regulated in proteobacteria phylum by comparing E. coli with other 6 proteobacteria including those 4 species, Klebsiella pneumonia (γ-proteobacteria), and …

2007年10月5日 · Fur is a DNA binding protein that represses bacterial iron uptake systems. Eleven footprinted Escherichia coli Fur binding sites were used to create an initial information theory model of Fur binding, which was then refined by adding 13 experimentally confirmed sites.

2014年3月15日 · In E. coli, the level of active Fur is the result of many factors involving not only iron availability but also the control carried out by OxyR and SoxRS that activate fur expression [118].

Our analysis of the affinity and stoichiometry of DNA binding by B. subtilis Fur, together with a reinterpretation of previously described studies of Escherichia coli Fur, supports a model in which the 19-bp Fur box represents overlapping recognition sites for two Fur dimers bound to opposite faces of the DNA helix.

2006年7月28日 · Escherichia coli Fur is a global transcriptional regulator that controls the expression of more than 90 genes mainly implicated in iron uptake but also in other fundamental processes, such as the regulation of oxidative stress, acid tolerance, and bacterial virulence determinants (1).

Our studies of the global transcription response of E. coli cells treated with GSNO and NaNO 2 showed that the E. coli response to reactive nitrogen species during aerobic growth in rich media is a composite response in which NorR and Fur have major roles, SoxR and OxyR have minor roles, and additional regulators remain to be identified. It is ...

The ferric uptake regulator (Fur) plays a critical role in the transcriptional regulation of iron metabolism. However, the full regulatory potential of Fur remains undefined. Here we comprehensively reconstruct the Fur transcriptional regulatory network in Escherichia coli K-12 MG1655 in response to iron availability using genome-wide measurements.

While some organisms have additional regulatory proteins to regulate Fur expression, like the catabolite activator protein in E. coli , RpoS in V. vulnificus , and NikR in H. pylori , autoregulation of Fur is the most conserved mechanism of fur regulation. Fur represses its own expression under iron-replete conditions.

2014年8月12日 · Fur was found to play a role in the virulence of many bacteria, including Staphylococcus aureus, Vibrio cholerae, Neisseria species, Yersinia species, and E. coli (52, 53). Fur repression occurs under iron-depleted conditions and is achieved by binding of Fur dimers to Fur boxes of target promoters.